Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/124588
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Type: Journal article
Title: Familial adult myoclonic epilepsy type 1 SAMD12 TTTCA repeat expansion arose 17,000 years ago and is present in Sri Lankan and Indian families
Author: Bennett, M.F.
Oliver, K.L.
Regan, B.M.
Bellows, S.T.
Schneider, A.L.
Rafehi, H.
Sikta, N.
Crompton, D.E.
Coleman, M.
Hildebrand, M.S.
Corbett, M.A.
Kroes, T.
Gecz, J.
Scheffer, I.E.
Berkovic, S.F.
Bahlo, M.
Citation: European Journal of Human Genetics, 2020; 28(7):973-978
Publisher: European Society of Human Genetics
Issue Date: 2020
ISSN: 1018-4813
1476-5438
Statement of
Responsibility: 
Mark F. Bennett, Karen L. Oliver, Brigid M. Regan, Susannah T. Bellows ... Mark Corbett ... Jozef Gecz ... at al.
Abstract: Familial adult myoclonic epilepsy 1 (FAME1), first recognised in Japanese families, was recently shown to be caused by a TTTCA repeat insertion in intron 4 of SAMD12 on chromosome 8. We performed whole genome sequencing on two families with FAME, one of Sri Lankan origin and the other of Indian origin, and identified a TTTCA repeat insertion in SAMD12 in both families. Haplotype analysis revealed that both families shared the same core ancestral haplotype reported in Japanese and Chinese families with FAME1. Mutation dating, based on the length of shared haplotypes, estimated the age of the ancestral haplotype to be ~670 generations, or 17,000 years old. Our data extend the geographic range of this repeat expansion to Southern Asia and potentially implicate an even broader regional distribution given the age of the variant. This finding suggests patients of Asian ancestry with suspected FAME should be screened for the SAMD12 TTTCA expansion.
Keywords: Humans
Epilepsies, Myoclonic
Nerve Tissue Proteins
Pedigree
Founder Effect
Haplotypes
Mutation
India
Sri Lanka
Female
Male
Description: Published: 16 March 2020
Rights: © European Society of Human Genetics 2020
DOI: 10.1038/s41431-020-0606-z
Grant ID: http://purl.org/au-research/grants/nhmrc/1155224
http://purl.org/au-research/grants/nhmrc/1091593
http://purl.org/au-research/grants/nhmrc/GNT1102971
http://purl.org/au-research/grants/nhmrc/1079058
http://purl.org/au-research/grants/nhmrc/1063799
http://purl.org/au-research/grants/nhmrc/1104831
http://purl.org/au-research/grants/nhmrc/1129054
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