Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/124590
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Type: Journal article
Title: Subcortical shape alterations in major depressive disorder: findings from the ENIGMA major depressive disorder working group
Author: Ho, T.C.
Gutman, B.
Pozzi, E.
Grabe, H.J.
Hosten, N.
Wittfeld, K.
Völzke, H.
Baune, B.
Dannlowski, U.
Förster, K.
Grotegerd, D.
Redlich, R.
Jansen, A.
Kircher, T.
Krug, A.
Meinert, S.
Nenadic, I.
Opel, N.
Dinga, R.
Veltman, D.J.
et al.
Citation: Human Brain Mapping, 2021; 43(1):341-351
Publisher: Wiley
Issue Date: 2021
ISSN: 1065-9471
1097-0193
Statement of
Responsibility: 
Tiffany C. Ho ... Bernhard Baune ... et al.
Abstract: Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, ENIGMA, to identify reliable neural correlates of major depressive disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work by precisely mapping localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subcortical structures: nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus. Harmonized data processing and statistical analyses were conducted locally at each site, and findings were aggregated by meta-analysis. Relative to CTL, patients with adolescent-onset MDD (≤ 21 years) had lower thickness and surface area of the subiculum, cornu ammonis (CA) 1 of the hippocampus and basolateral amygdala (Cohen's d = -0.164 to -0.180). Relative to first-episode MDD, recurrent MDD patients had lower thickness and surface area in the CA1 of the hippocampus and the basolateral amygdala (Cohen's d = -0.173 to -0.184). Our results suggest that previously reported MDD-associated volumetric differences may be localized to specific subfields of these structures that have been shown to be sensitive to the effects of stress, with important implications for mapping treatments to patients based on specific neural targets and key clinical features.
Keywords: ENIGMA
amygdala
hippocampus
major depressive disorder (MDD)
nucleus accumbens
shape analysis
Description: First published:21 March 2020
Rights: © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
DOI: 10.1002/hbm.24988
Grant ID: http://purl.org/au-research/grants/nhmrc/1140764
Appears in Collections:Aurora harvest 4
Psychiatry publications

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