Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/124630
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Type: Journal article
Title: Sustained cerebrovascular and cognitive benefits of resveratrol in postmenopausal women
Author: Thaung Zaw, J.J.
Howe, P.R.C.
Wong, R.H.X.
Citation: Nutrients, 2020; 12(3):828-1-828-14
Publisher: MDPI
Issue Date: 2020
ISSN: 2072-6643
2072-6643
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Responsibility: 
Jay Jay Thaung Zaw, Peter R.C. Howe, and Rachel H.X. Wong
Abstract: Deficits in the cerebral microcirculation contribute to age-related cognitive decline. In a pilot study of postmenopausal women, we found that supplementation with a low dose of resveratrol, a phytoestrogen, for 14 weeks improved cerebrovascular and cognitive functions. We have since undertaken a larger, longer term study to confirm these benefits. Postmenopausal women aged 45-85 years (n = 129) were randomized to take placebo or 75 mg trans-resveratrol twice daily for 12 months. Effects on cognition, cerebral blood flow, cerebrovascular responsiveness (CVR) and cardiometabolic markers (blood pressure, diabetes markers and fasting lipids) were assessed. Compared to placebo, resveratrol improved overall cognitive performance (P < 0.001) and attenuated the decline in CVR to cognitive stimuli (P = 0.038). The latter effect was associated with reduction of fasting blood glucose (r = -0.339, P = 0.023). This long-term study confirms that regular consumption of resveratrol can enhance cognitive and cerebrovascular functions in postmenopausal women, with the potential to slow cognitive decline due to ageing and menopause.
Keywords: Resveratrol; ageing; menopause; cognitive decline; cerebrovascular function; neurovascular coupling; phytoestrogen; nutraceutical
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI: 10.3390/nu12030828
Grant ID: http://purl.org/au-research/grants/nhmrc/1106170
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