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Type: Journal article
Title: The potential role of growth hormone on the endometrium in assisted reproductive technology
Author: Liu, F.T.
Wu, Z.
Yan, J.
Norman, R.J.
Li, R.
Citation: Frontiers in Endocrinology, 2020; 11:49-1-49-8
Publisher: Frontiers Media
Issue Date: 2020
ISSN: 1664-2392
Statement of
Fen-Ting Liu, Ze Wu, Jie Yan, Robert J. Norman and Rong Li
Abstract: Growth hormone (GH) has been considered as an adjuvant treatment in human assisted reproductive technology (ART) for several years. Its action was largely attributed to an improvement of ovarian function and less emphasis was paid to its role in the uterus. However, there is increasing evidence that GH and its receptors are expressed and have actions in the endometrium and may play an important role in modifying endometrial receptivity. Thus, in this review, we firstly describe the existence of GH receptors in endometrium and then summarize the effects of GH on the endometrium in clinical situations and the underlying mechanisms of GH in the regulation of endometrial receptivity. Finally, we briefly review the potential risks of GH in ART and consider rationalized use of GH treatment in ART.
Keywords: Growth hormone; endometrial receptivity; mechanisms; risk; ART
Rights: © 2020 Liu, Wu, Yan, Norman and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI: 10.3389/fendo.2020.00049
Appears in Collections:Aurora harvest 8
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