Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/124925
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Type: Journal article
Title: Creating nano-engineered biomaterials with well-defined surface descriptors
Author: Visalakshan, R.
Macgregor, M.
Cavallaro, A.
Sasidharan, S.
Bachhuka, A.
Mierczynska-Vasilev, A.
Hayball, J.
Vasilev, K.
Citation: ACS Applied Nano Materials, 2018; 1(6):2796-2807
Publisher: American Chemical Society
Issue Date: 2018
ISSN: 2574-0970
2574-0970
Statement of
Responsibility: 
Rahul M. Visalakshan, Melanie N. MacGregor, Alex A. Cavallaro, Salini Sasidharan, Akash Bachhuka, Agnieszka M. Mierczynska-Vasilev, John D. Hayball, and Krasimir Vasilev
Abstract: The importance of nanostructured surfaces in a range of technological and biological processes is well-documented within literature, yet often ill-understood. Simple and reliable methods for the preparation of nanotextured surfaces are required to advance both fundamental understandings of nanoscale phenomena and our capacity to design nano-engineered materials for specific applications. Nano-engineered surfaces are, for instance, needed to shed light on the effect of nanostructures’ size and density on immune cells cytokine production. In applied bioengineering, nanostructured artificial surfaces could be specifically tailored to enhance the osteo-integration of implants. This study presents a versatile, plasma polymer enabled method for the generation of surfaces with well-defined nanotopography and tailored outermost surface chemistry. This was achieved by finely controlling the covalent bonding of gold nanoparticles of desired size to plasma-deposited poly(methyloxazoline) interlayer deposited on the material substrate. An additional 5 nm thin polymer was deposited over the nanostructures providing a uniformly tailored outermost surface chemistry while preserving the topography. This rapid, versatile, substrate independent, and scalable strategy for the preparation of a well-defined nanotopography surface has promising prospects in many fields relying on surface engineering, including food and membrane technologies, biomaterial and environmental engineering, sensing, marine sciences, and even pollution control.
Keywords: Well-defined nanotopography; polymethyloxazoline; homogeneous chemistry; plasma polymerization; biomaterial; nanoscale roughness
Rights: © 2018 American Chemical Society
RMID: 1000014092
DOI: 10.1021/acsanm.8b00458
Grant ID: http://purl.org/au-research/grants/arc/DP15104212
http://purl.org/au-research/grants/arc/DP180101254
http://purl.org/au-research/grants/nhmrc/1122825
http://purl.org/au-research/grants/nhmrc/1032738
Appears in Collections:Chemical Engineering publications

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