Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/125039
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dc.contributor.authorHou, L.en
dc.contributor.authorChen, S.en
dc.contributor.authorShi, W.en
dc.contributor.authorChen, H.en
dc.contributor.authorLiang, Y.en
dc.contributor.authorWang, X.en
dc.contributor.authorTan, J.en
dc.contributor.authorWang, Y.en
dc.contributor.authorDeng, X.en
dc.contributor.authorZhan, M.en
dc.contributor.authorLong, J.en
dc.contributor.authorCai, G.en
dc.contributor.authorLuo, S.en
dc.contributor.authorZhang, C.en
dc.contributor.authorLiu, J.en
dc.contributor.authorLeung, J.en
dc.contributor.authorXie, L.en
dc.date.issued2020en
dc.identifier.citationEcotoxicology and Environmental Safety, 2020; 195:110496-1-110496-10en
dc.identifier.issn0147-6513en
dc.identifier.issn1090-2414en
dc.identifier.urihttp://hdl.handle.net/2440/125039-
dc.description.abstractThe impact of progestins (i.e. synthetic forms of progesterone) on aquatic organisms has drawn increasing attention due to their widespread occurrence in the aquatic environments and potential effects on the endocrine system of fish. In this study, the effects of norethindrone (NET, a progestin) on the reproductive behavior, sex hormone production and transcriptional expressions were evaluated by exposing female zebrafish to NET at 0, 3.1, 36.2 and 398.6 ng L⁻¹ for 60 days. Results showed that NET impaired the mating behaviors of female at 36.2 and 398.6 ng L⁻¹ exhibited by males and increased the frequency of atretic follicular cells in the ovary exposed to NET at 398.6 ng L⁻¹. As for sex hormones, plasma testosterone concentration in zebrafish increased, while estradiol concentration decreased. Up-regulation of genes (Npr, Mpra, Mprβ, Fshβ, Lβ, Tshb, Nis and Dio2) was detected in the brain of fish exposed to NET at 398.6 ng L⁻¹. The transcriptional levels of genes (Esr1, Vtg1, Ar, Cyp19a, Cyp11b and Ptgs2) were generally inhibited in the ovary of zebrafish by NET at 398.6 ng L⁻¹. Moreover, the transcripts of genes (Vtg1, Esr1, Ar and Pgr) in the liver were reduced by NET at 36.2 and 398.6 ng L⁻¹. Our findings suggest that NET can potentially diminish the of fish populations not only by damaging their reproductive organs, but also by altering their mating behavior through the changes in the expressions of genes responsible for the production of sex hormones.en
dc.description.statementofresponsibilityLiping Hou, Shanduo Chen, Wenjun Shi, Hongxing Chen, Yanqiu Liang, Xiaolan Wang, Jiefeng Tan, Yifan Wang, Xikai Deng, Manjun Zhan, Jianzhao Long, Guowei Cai, Shaowen Luo, Cuiping Zhang, Juan Liu, Jonathan Y.S. Leung, Lingtian Xieen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2020 Elsevier Inc. All rights reserved.en
dc.subjectReproductive behaviour; norethindrone; zebrafish; endocrine disrupting chemical; steroidogenesis; gene expressionen
dc.titleNorethindrone alters mating behaviors, ovary histology, hormone production and transcriptional expression of steroidogenic genes in zebrafish (Danio rerio)en
dc.typeJournal articleen
dc.identifier.rmid1000017989en
dc.identifier.doi10.1016/j.ecoenv.2020.110496en
dc.identifier.pubid526198-
pubs.library.collectionEnvironment Institute publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidLeung, J. [0000-0001-5846-3401]en
Appears in Collections:Environment Institute publications

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