Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/125199
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Type: Journal article
Title: Fabrication of a cartilage patch by fusing hydrogel-derived cell aggregates onto electrospun film
Author: Zhang, J.
Yun, S.
Du, Y.
Zannettino, A.C.W.
Zhang, H.
Citation: Tissue Engineering Part A, 2020; 26(15-16):1-9
Publisher: Mary Ann Liebert
Issue Date: 2020
ISSN: 1937-3341
1937-335X
Statement of
Responsibility: 
Jiabin Zhang, Seonho Yun, Yuguang Du, Andrew C.W. Zannettino and Hu Zhang
Abstract: Irregular defects at sites of degenerative cartilage often accompany osteoarthritis (OA). The development of novel cells/biomaterials-based cartilage tissue engineering methods to address these defects may provide a durable approach to hinder the development of OA. In the present study, we fabricated a neo-cartilage patch by fusing cell aggregates onto a biodegradable nanofiber film for degenerative cartilage repair. Human mesenchymal stem/stromal cell (MSC) aggregates were prepared and induced for chondrogenesis in a thermosensitive hydrogel, poly (<i>N</i>-isopropylacrylamide-co-acrylic acid) (p(NIPAAm-AA)). Cell migration mediated the formation of cell aggregates in the thermosensitive hydrogel and led to a cell-dense hollow shell structure. The chondrocytes derived from MSC aggregates in the hydrogel were evidenced by the expression of chondrogenesis-related genes and extracellular matrices (ECMs). They were fused onto an electrospun film by mechanical force and spatial confinement to generate a neo-cartilage patch. The fabricated neo-cartilage patches may be able to integrate into the irregular defects under compressive stresses and achieve cartilage regeneration <i>in vivo</i>.
Keywords: Hydrogel; chondrogenesis; human mesenchymal stem/stromal cell; electrospinning; cell aggregates; cartilage regeneration
Description: Published Online:19 Mar 2020
Rights: ©t 2020, Mary Ann Liebert, Inc., publishers
DOI: 10.1089/ten.TEA.2019.0318
Grant ID: http://purl.org/au-research/grants/arc/DP160104632
Appears in Collections:Aurora harvest 8
Chemical Engineering publications

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