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dc.contributor.authorZhang, J.-
dc.contributor.authorYun, S.-
dc.contributor.authorDu, Y.-
dc.contributor.authorZannettino, A.C.W.-
dc.contributor.authorZhang, H.-
dc.identifier.citationTissue Engineering Part A, 2020; 26(15-16):1-9-
dc.descriptionPublished Online:19 Mar 2020-
dc.description.abstractIrregular defects at sites of degenerative cartilage often accompany osteoarthritis (OA). The development of novel cells/biomaterials-based cartilage tissue engineering methods to address these defects may provide a durable approach to hinder the development of OA. In the present study, we fabricated a neo-cartilage patch by fusing cell aggregates onto a biodegradable nanofiber film for degenerative cartilage repair. Human mesenchymal stem/stromal cell (MSC) aggregates were prepared and induced for chondrogenesis in a thermosensitive hydrogel, poly (<i>N</i>-isopropylacrylamide-co-acrylic acid) (p(NIPAAm-AA)). Cell migration mediated the formation of cell aggregates in the thermosensitive hydrogel and led to a cell-dense hollow shell structure. The chondrocytes derived from MSC aggregates in the hydrogel were evidenced by the expression of chondrogenesis-related genes and extracellular matrices (ECMs). They were fused onto an electrospun film by mechanical force and spatial confinement to generate a neo-cartilage patch. The fabricated neo-cartilage patches may be able to integrate into the irregular defects under compressive stresses and achieve cartilage regeneration <i>in vivo</i>.-
dc.description.statementofresponsibilityJiabin Zhang, Seonho Yun, Yuguang Du, Andrew C.W. Zannettino and Hu Zhang-
dc.publisherMary Ann Liebert-
dc.rights©t 2020, Mary Ann Liebert, Inc., publishers-
dc.subjectHydrogel; chondrogenesis; human mesenchymal stem/stromal cell; electrospinning; cell aggregates; cartilage regeneration-
dc.titleFabrication of a cartilage patch by fusing hydrogel-derived cell aggregates onto electrospun film-
dc.typeJournal article-
dc.identifier.orcidZannettino, A.C.W. [0000-0002-6646-6167]-
dc.identifier.orcidZhang, H. [0000-0003-4178-6401]-
Appears in Collections:Aurora harvest 8
Chemical Engineering publications

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