Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/125708
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Type: Journal article
Title: Role of aquaporin 1 signalling in cancer development and progression
Author: Tomita, Y.
Dorward, H.
Yool, A.
Smith, E.
Townsend, A.
Price, T.
Hardingham, J.
Citation: International Journal of Molecular Sciences, 2017; 18(2):299-1-299-17
Publisher: MDPI AG
Issue Date: 2017
ISSN: 1661-6596
1422-0067
Statement of
Responsibility: 
Yoko Tomita, Hilary Dorward, Andrea J. Yool, Eric Smith, Amanda R. Townsend, Timothy J. Price and Jennifer E. Hardingham
Abstract: Cancer is a major health burden worldwide. Despite the advances in our understanding of its pathogenesis and continued improvement in cancer management and outcomes, there remains a strong clinical demand for more accurate and reliable biomarkers of metastatic progression and novel therapeutic targets to abrogate angiogenesis and tumour progression. Aquaporin 1 (AQP1) is a small hydrophobic integral transmembrane protein with a predominant role in trans-cellular water transport. Recently, over-expression of AQP1 has been associated with many types of cancer as a distinctive clinical prognostic factor. This has prompted researchers to evaluate the link between AQP1 and cancer biological functions. Available literature implicates the role of AQP1 in tumour cell migration, invasion and angiogenesis. This article reviews the current understanding of AQP1-facilitated tumour development and progression with a focus on regulatory mechanisms and downstream signalling pathways.
Keywords: aquaporin 1; carcinogenesis; tumour angiogenesis; tumour cell migration
Description: Published: 29 January 2017
Rights: © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI: 10.3390/ijms18020299
Appears in Collections:Aurora harvest 8
Surgery publications

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