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Type: Journal article
Title: Aberrant expression of high mobility group box protein 1 in the idiopathic inflammatory myopathies
Author: Day, J.
Otto, S.
Cash, K.
Eldi, P.
Hissaria, P.
Proudman, S.
Limaye, V.
Hayball, J.D.
Citation: Frontiers in Cell and Developmental Biology, 2020; 8
Publisher: Frontiers
Issue Date: 2020
ISSN: 2296-634X
Statement of
Jessica Day ... Pravin Hissaria, Susanna Proudman, Vidya Limaye and John D. Hayball ... et al.
Abstract: Introduction: High Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus. We postulate aberrant HMGB1 expression in immune-mediated necrotising myopathy (IMNM). Methods: Herein, we compare HMGB1 expression (serological and sarcoplasmic) in patients with IMNM with that of other myositis subtypes using immunohistochemistry and ELISA. Results: IMNM (n = 62) and inclusion body myositis (IBM, n = 14) patients had increased sarcoplasmic HMGB1 compared with other myositis patients (n = 46). Sarcoplasmic HMGB1 expression correlated with muscle weakness and histological myonecrosis, inflammation, regeneration and autophagy. Serum HMGB1 levels were elevated in patients with IMNM, dermatomyositis and polymositis, and those myositis patients with extramuscular inflammatory features. Discussion: Aberrant HMGB1 expression occurs in myositis patients and correlates with weakness. A unique expression profile of elevated sarcoplasmic and serum HMGB1 was detected in IMNM.
Keywords: Myositis; idiopathic inflammatory myopathy; HMGB1; immune-mediated necrotising myopathy; immune-mediated necrotizing myopathy; inclusion body myositis; necrotising autoimmune myopathy; necrotizing autoimmune myopathy
Rights: © 2020 Day, Otto, Cash, Eldi, Hissaria, Proudman, Limaye and Hayball. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI: 10.3389/fcell.2020.00226
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