Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/126030
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dc.contributor.authorDeng, Q.en
dc.contributor.authorMa, D.en
dc.contributor.authorShi, Z.en
dc.contributor.authorHuang, W.en
dc.contributor.authorDu, X.en
dc.contributor.authorGao, W.en
dc.contributor.authorZhu, X.en
dc.contributor.authorLei, L.en
dc.contributor.authorZhang, M.en
dc.contributor.authorSun, G.en
dc.contributor.authorYuan, X.en
dc.contributor.authorLi, X.en
dc.contributor.authorWang, Z.en
dc.contributor.authorLiu, G.en
dc.contributor.authorLi, X.en
dc.date.issued2016en
dc.identifier.citationJournal of Animal Physiology and Animal Nutrition, 2016; 100(2):331-336en
dc.identifier.issn0931-2439en
dc.identifier.issn1439-0396en
dc.identifier.urihttp://hdl.handle.net/2440/126030-
dc.description.abstractβ-Hydroxybutyricacid (BHBA) is an important metabolite that involved in the development of ketosis and fatty liver in dairy cows. Dairy cows with fatty liver displayed high blood concentration of BHBA and very low-density lipoprotein (VLDL) assembly. The effects of BHBA on VLDL synthesis and assembly in hepatocytes of cows were unclear. In this study, bovine hepatocytes were cultured and treated with different concentrations of BHBA. We found that BHBA treatment upregulated the mRNA and protein levels of apolipoprotein B100 (ApoB 100), apolipoprotein E (ApoE) and microsomal triglyceride transfer protein (MTTP) and showed in a firstly increased and then decreased trend. Meanwhile, the mRNA and protein levels of LDLR showed in a reverse trend. Consequently, VLDL content was significantly increased in medium-dose BHBA treatment group, while decreased in high-dose group. These results indicate that the effects of BHBA on the VLDL synthesis showed in a dose-dependent manner that low levels of BHBA increase VLDL synthesis and high levels of BHBA decrease VLDL synthesis.en
dc.description.statementofresponsibilityQ. Deng, D. Ma, Z. Shi, W. Huang, X. Du, W. Gao ... et al.en
dc.language.isoenen
dc.publisherWiley Online Libraryen
dc.rightsJournal of Animal Physiology and Animal Nutrition © 2015 Blackwell Verlag GmbHen
dc.subjectβ ‐Hydroxybutyricacid; bovine hepatocyte; very low‐density lipoprotein; negative energy balance; synthesis and assemblyen
dc.titleEffects of β-hydroxybutyricacid on the synthesis and assembly of very low-density lipoprotein in bovine hepatocytes in vitroen
dc.title.alternativeEffects of beta-hydroxybutyricacid on the synthesis and assembly of very low-density lipoprotein in bovine hepatocytes in vitroen
dc.typeJournal articleen
dc.identifier.rmid0030084562en
dc.identifier.doi10.1111/jpn.12380en
dc.identifier.pubid403048-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHuang, W. [0000-0001-9400-3840]en
Appears in Collections:Medicine publications

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