Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: An investigation of antihypertensive class, dementia, and cognitive decline
Author: Peters, R.
Yasar, S.
Anderson, C.S.
Andrews, S.
Antikainen, R.
Arima, H.
Beckett, N.
Beer, J.C.
Bertens, A.S.
Booth, A.
van Boxtel, M.
Brayne, C.
Brodaty, H.
Carlson, M.C.
Chalmers, J.
Corrada, M.
DeKosky, S.
Derby, C.
Dixon, R.A.
Forette, F.
et al.
Citation: Neurology, 2020; 94(3):1-15
Publisher: American Academy of Neurology
Issue Date: 2020
ISSN: 0028-3878
Statement of
Ruth Peters, Sevil Yasar, Craig S. Anderson, Shea Andrews, Riitta Antikainen ... Phillip Tully ... et al.
Abstract: Objective High blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular antihypertensive class was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original participant data.Methods To identify suitable studies, MEDLINE, Embase, and PsycINFO and preexisting study consortia were searched from inception to December 2017. Authors of prospective longitudinal human studies or trials of antihypertensives were contacted for data sharing and collaboration. Outcome measures were incident dementia or incident cognitive decline (classified using the reliable change index method). Data were separated into mid and late-life (>65 years) and each antihypertensive class was compared to no treatment and to treatment with other antihypertensives. Meta-analysis was used to synthesize data.Results Over 50,000 participants from 27 studies were included. Among those aged >65 years, with the exception of diuretics, we found no relationship by class with incident cognitive decline or dementia. Diuretic use was suggestive of benefit in some analyses but results were not consistent across follow-up time, comparator group, and outcome. Limited data precluded meaningful analyses in those ≤65 years of age.Conclusion Our findings, drawn from the current evidence base, support clinical freedom in the selection of antihypertensive regimens to achieve blood pressure goals.Clinical trials registration The review was registered with the international prospective register of systematic reviews (PROSPERO), registration number CRD42016045454.
Keywords: Humans
Antihypertensive Agents
Aged, 80 and over
Middle Aged
Cognitive Dysfunction
Rights: © 2019 American Academy of Neurology
DOI: 10.1212/WNL.0000000000008732
Appears in Collections:Aurora harvest 4
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.