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Type: Journal article
Title: Polyinosinic: polycytidylic acid and murine cytomegalovirus modulate expression of murine IL-10 and IL-21 in white adipose tissue
Author: Garcia-Valtanen, P.
Guzman-Genuino, R.M.
Hayball, J.D.
Diener, K.R.
Citation: Viruses, 2020; 12(5):569-1-569-16
Publisher: MDPI
Issue Date: 2020
ISSN: 1999-4915
Statement of
Pablo Garcia-Valtanen, Ruth Marian Guzman-Genuino, John D. Hayball and Kerrilyn R. Diener
Abstract: White adipose tissue (WAT) produces interleukin-10 and other immune suppressors in response to pathogen-associated molecular patterns (PAMPs). It also homes a subset of B-cells specialized in the production of IL-10, referred to as regulatory B-cells. We investigated whether viral stimuli, polyinosinic: polycytidylic acid (poly(I:C)) or whole replicative murine cytomegalovirus (MCMV), could stimulate the expression of IL-10 in murine WAT using in vivo and ex vivo approaches. Our results showed that in vivo responses to systemic administration of poly(I:C) resulted in high levels of endogenously-produced IL-10 and IL-21 in WAT. In ex vivo WAT explants, a subset of B-cells increased their endogenous IL-10 expression in response to poly(I:C). Finally, MCMV replication in WAT explants resulted in decreased IL-10 levels, opposite to the effect seen with poly(I:C). Moreover, downregulation of IL-10 correlated with relatively lower number of Bregs. To our knowledge, this is the first report of IL-10 expression by WAT and WAT-associated B-cells in response to viral stimuli.
Keywords: Murine cytomegalovirus; polyinosinic: polycytidylic acid; white adipose tissue; regulatory B-cells; interleukin-10
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI: 10.3390/v12050569
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