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https://hdl.handle.net/2440/126134
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Type: | Journal article |
Title: | Resting state functional connectivity is associated with motor pathway integrity and upper-limb behavior in chronic stroke |
Author: | Hordacre, B. Goldsworthy, M.R. Welsby, E. Graetz, L. Ballinger, S. Hillier, S. |
Citation: | Neurorehabilitation and Neural Repair, 2020; 34(6):547-557 |
Publisher: | SAGE Publications |
Issue Date: | 2020 |
ISSN: | 1545-9683 1552-6844 |
Statement of Responsibility: | Brenton Hordacre, Mitchell R. Goldsworthy, Ellana Welsby, Lynton Graetz, Sophie Ballinger, and Susan Hillier |
Abstract: | Background. Resting state functional connectivity (RSFC) is a developmental priority for stroke recovery. Objective. To determine whether (1) RSFC differs between stroke survivors based on integrity of descending motor pathways; (2) RSFC is associated with upper-limb behavior in chronic stroke; and (3) the relationship between interhemispheric RSFC and upper-limb behavior differs based on descending motor pathway integrity. Methods. A total of 36 people with stroke (aged 64.4 ± 11.1 years, time since stroke 4.0 ± 2.8 years) and 25 healthy adults (aged 67.3 ± 6.7 years) participated in this study. RSFC was estimated from electroencephalography (EEG) recordings. Integrity of descending motor pathways was ascertained using transcranial magnetic stimulation to determine motor-evoked potential (MEP) status and magnetic resonance imaging to determine lesion overlap and fractional anisotropy of the corticospinal tract (CST). For stroke participants, upper-limb motor behavior was assessed using the Fugl-Meyer test, Action Research Arm Test and grip strength. Results. β-Frequency interhemispheric sensorimotor RSFC was greater for MEP+ stroke participants compared with MEP- (P = .020). There was a significant positive correlation between β RSFC and upper-limb behavior (P = .004) that appeared to be primarily driven by the MEP+ group. A hierarchical regression identified that the addition of β RSFC to measures of CST integrity explained greater variance in upper-limb behavior (R² change = 0.13; P = .01). Conclusions. This study provides insight to understand the role of EEG-based measures of interhemispheric network activity in chronic stroke. Resting state interhemispheric connectivity was positively associated with upper-limb behavior for stroke survivors where residual integrity of descending motor pathways was maintained. |
Keywords: | Stroke; motor cortex; electroencephalography; resting state functional connectivity; magnetic resonance imaging |
Rights: | © The Author(s) 2020 Article reuse guidelines: sagepub.com/journals-permissions |
DOI: | 10.1177/1545968320921824 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1125054 http://purl.org/au-research/grants/nhmrc/1102272 |
Published version: | http://dx.doi.org/10.1177/1545968320921824 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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