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|dc.identifier.citation||Neurorehabilitation and Neural Repair, 2020; 34(6):547-557||en|
|dc.description.abstract||Background. Resting state functional connectivity (RSFC) is a developmental priority for stroke recovery. Objective. To determine whether (1) RSFC differs between stroke survivors based on integrity of descending motor pathways; (2) RSFC is associated with upper-limb behavior in chronic stroke; and (3) the relationship between interhemispheric RSFC and upper-limb behavior differs based on descending motor pathway integrity. Methods. A total of 36 people with stroke (aged 64.4 ± 11.1 years, time since stroke 4.0 ± 2.8 years) and 25 healthy adults (aged 67.3 ± 6.7 years) participated in this study. RSFC was estimated from electroencephalography (EEG) recordings. Integrity of descending motor pathways was ascertained using transcranial magnetic stimulation to determine motor-evoked potential (MEP) status and magnetic resonance imaging to determine lesion overlap and fractional anisotropy of the corticospinal tract (CST). For stroke participants, upper-limb motor behavior was assessed using the Fugl-Meyer test, Action Research Arm Test and grip strength. Results. β-Frequency interhemispheric sensorimotor RSFC was greater for MEP+ stroke participants compared with MEP- (P = .020). There was a significant positive correlation between β RSFC and upper-limb behavior (P = .004) that appeared to be primarily driven by the MEP+ group. A hierarchical regression identified that the addition of β RSFC to measures of CST integrity explained greater variance in upper-limb behavior (R² change = 0.13; P = .01). Conclusions. This study provides insight to understand the role of EEG-based measures of interhemispheric network activity in chronic stroke. Resting state interhemispheric connectivity was positively associated with upper-limb behavior for stroke survivors where residual integrity of descending motor pathways was maintained.||en|
|dc.description.statementofresponsibility||Brenton Hordacre, Mitchell R. Goldsworthy, Ellana Welsby, Lynton Graetz, Sophie Ballinger, and Susan Hillier||en|
|dc.rights||© The Author(s) 2020 Article reuse guidelines: sagepub.com/journals-permissions||en|
|dc.subject||Stroke; motor cortex; electroencephalography; resting state functional connectivity; magnetic resonance imaging||en|
|dc.title||Resting state functional connectivity is associated with motor pathway integrity and upper-limb behavior in chronic stroke||en|
|dc.identifier.orcid||Hordacre, B. [0000-0002-7129-6684]||en|
|dc.identifier.orcid||Goldsworthy, M.R. [0000-0002-0688-9475]||en|
|dc.identifier.orcid||Hillier, S. [0000-0002-6071-6137]||en|
|Appears in Collections:||Medicine publications|
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