Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/126286
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Type: Journal article
Title: People with schizophrenia and depression have a low omega-3 index
Author: Parletta, N.
Zarnowiecki, D.
Cho, J.
Wilson, A.
Procter, N.
Gordon, A.
Bogomolova, S.
O'Dea, K.
Strachan, J.
Ballestrin, M.
Champion, A.
Meyer, B.J.
Citation: Prostaglandins, Leukotrienes and Essential Fatty Acids, 2016; 110:42-47
Publisher: Elsevier
Issue Date: 2016
ISSN: 0952-3278
1532-2823
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Responsibility: 
Natalie Parletta, Dorota Zarnowiecki, Jihyun Cho, Amy Wilson, Nicholas Procter, Andrea Gordon, Svetlana Bogomolova, Kerin O’Dea, John Strachan, Matt Ballestrin, Andrew Champion, Barbara J Meyer
Abstract: Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.
Keywords: Polyunsaturated fatty acids; omega-3; omega-3 index; mental illness; depression; schizophrenia; cardiovascular disease
Rights: © 2016 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.plefa.2016.05.007
Grant ID: http://purl.org/au-research/grants/nhmrc/320860
http://purl.org/au-research/grants/nhmrc/631947
Published version: http://dx.doi.org/10.1016/j.plefa.2016.05.007
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