Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/126293
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Type: Journal article
Title: Maladaptive avoidance patterns in Parkinson's disease are exacerbated by symptoms of depression
Author: Sheynin, J.
Baetu, I.
Collins-Praino, L.E.
Myers, C.E.
Winwood-Smith, R.
Moustafa, A.A.
Citation: Behavioural Brain Research, 2020; 382:112473-1-112473-9
Publisher: Elsevier BV
Issue Date: 2020
ISSN: 0166-4328
1872-7549
Statement of
Responsibility: 
Jony Sheynin, Irina Baetu, Lyndsey E. Collins-Praino, Catherine E. Myers, Robyn Winwood-Smith, Ahmed A. Moustafa
Abstract: Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder, characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta. Given that dopamine is critically involved in learning and other cognitive processes, such as working memory, dopamine loss in PD has been linked both to learning abnormalities and to cognitive dysfunction more generally in the disease. It is unclear, however, whether avoidance behavior is impacted in PD. This is significant, as this type of instrumental behavior plays an important role in both decision-making and emotional (dys) function. Consequently, the aim of the present study was to examine avoidance learning and operant extinction in PD using a computer-based task. On this task, participants control a spaceship and attempt to shoot an enemy spaceship to gain points. They also learn to hide in safe areas to protect from (i.e., avoid) aversive events (on-screen explosions and point loss). The results showed that patients with PD (N = 25) acquired an avoidance response during aversive periods to the same extent as healthy age-matched controls (N = 19); however, patients demonstrated greater hiding during safe periods not associated with aversive events, which could represent maladaptive generalization of the avoidance response. Furthermore, this impairment was more pronounced during the extinction phase, and in patients who reported higher levels of depression. These results demonstrate for the first time that PD is associated with maladaptive avoidance patterns, which could possibly contribute to the emergence of depression in the disease.
Keywords: Parkinson’s disease; avoidance; extinction; generalization; depression; computer-based task
Description: Available online 11 January 2020
Rights: © 2020 Elsevier B.V. All rights reserved.
RMID: 1000012706
DOI: 10.1016/j.bbr.2020.112473
Appears in Collections:Psychology publications

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