Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/126883
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dc.contributor.authorJankovic-Karasoulos, T.en
dc.contributor.authorFurness, D.L.en
dc.contributor.authorLeemaqz, S.Y.en
dc.contributor.authorDekker, G.A.en
dc.contributor.authorGrzeskowiak, L.E.en
dc.contributor.authorGrieger, J.A.en
dc.contributor.authorAndraweera, P.H.en
dc.contributor.authorMcCullough, D.en
dc.contributor.authorMcAninch, D.en
dc.contributor.authorMcCowan, L.M.en
dc.contributor.authorBianco-Miotto, T.en
dc.contributor.authorRoberts, C.T.en
dc.date.issued2021en
dc.identifier.citationMaternal and Child Nutrition, 2021; 17(1):e13064-1-e13064-17en
dc.identifier.issn1740-8695en
dc.identifier.issn1740-8709en
dc.identifier.urihttp://hdl.handle.net/2440/126883-
dc.description.abstractSingle nucleotide polymorphisms and pre- and peri-conception folic acid (FA) supplementation and dietary data were used to identify one-carbon metabolic factors associated with pregnancy outcomes in 3196 nulliparous women. In 325 participants, we also measured circulating folate, vitamin B12 and homocysteine. Pregnancy outcomes included preeclampsia (PE), gestational hypertension (GHT), small for gestational age (SGA), spontaneous preterm birth (sPTB) and gestational diabetes mellitus (GDM). Study findings show that maternal genotype MTHFR A1298C(CC) was associated with increased risk for PE, whereas TCN2 C766G(GG) had a reduced risk for sPTB. Paternal MTHFR A1298C(CC) and MTHFD1 G1958A(AA) genotypes were associated with reduced risk for sPTB, whereas MTHFR C677T(CT) genotype had an increased risk for GHT. FA supplementation was associated with higher serum folate and vitamin B12 concentrations, reduced uterine artery resistance index and increased birth weight. Women who supplemented with <800 μg daily FA at 15-week gestation had a higher incidence of PE (10.3%) compared with women who did not supplement (6.1%) or who supplemented with ≥800 μg (5.4%) (P < .0001). Higher serum folate levels were found in women who later developed GDM compared with women with uncomplicated pregnancies (Mean ± SD: 37.6 ± 8 nmol L-1 vs. 31.9 ± 11.2, P = .007). Fast food consumption was associated with increased risk for developing GDM, whereas low consumption of green leafy vegetables and fruit were independent risk factors for SGA and GDM and sPTB and SGA, respectively. In conclusion, maternal and paternal genotypes, together with maternal circulating folate and homocysteine concentrations, and pre- and early-pregnancy dietary factors, are independent risk factors for pregnancy complications.en
dc.description.statementofresponsibilityTanja Jankovic-Karasoulos, Denise L. Furness, Shalem Y. Leemaqz, Gustaaf A. Dekker, Luke E. Grzeskowiak, Jessica A. Grieger, Prabha H. Andraweera, Dylan McCullough, Dale McAninch, Lesley M. McCowan, Tina Bianco-Miotto, Claire T. Robertsen
dc.language.isoenen
dc.publisherWileyen
dc.rights© 2020 The Authors. Maternal & Child Nutrition published by John Wiley & Sons, Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectFolate; folic acid; maternal diet; neonatal outcomes; one-carbon metabolism; pregnancy outcomes; SNPen
dc.titleMaternal folate, one-carbon metabolism and pregnancy outcomesen
dc.typeJournal articleen
dc.identifier.rmid1000023882en
dc.identifier.doi10.1111/mcn.13064en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/519225en
dc.identifier.pubid539764-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidLeemaqz, S.Y. [0000-0003-4616-8426]en
dc.identifier.orcidDekker, G.A. [0000-0002-7362-6683]en
dc.identifier.orcidGrzeskowiak, L.E. [0000-0001-8554-4696]en
dc.identifier.orcidGrieger, J.A. [0000-0003-1515-948X]en
dc.identifier.orcidAndraweera, P.H. [0000-0003-2434-8370]en
dc.identifier.orcidMcAninch, D. [0000-0001-9735-6553]en
dc.identifier.orcidBianco-Miotto, T. [0000-0002-8431-5338]en
dc.identifier.orcidRoberts, C.T. [0000-0002-9250-2192]en
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