Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/126924
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Type: Journal article
Title: Effect of iodine and selenium on proliferation, viability, and oxidative stress in HTR-8/SVneo placental cells
Author: Habibi, N.
Jankovic-Karasoulos, T.
Leemaqz, S.Y.L.
Francois, M.
Zhou, S.J.
Leifert, W.R.
Perkins, A.V.
Roberts, C.T.
Bianco-Miotto, T.
Citation: Biological Trace Element Research, 2020; 199(4):1332-1344
Publisher: Springer
Issue Date: 2020
ISSN: 0163-4984
1559-0720
Statement of
Responsibility: 
Nahal Habibi, Tanja Jankovic-Karasoulos, Shalem Yiner-Lee Leemaqz, Maxime Francois, Shao Jia Zhou, Wayne R. Leifert ... et al.
Abstract: Adequate maternal micronutrition is vital for placental formation, fetal growth, and development. Oxidative stress adversely affects placental development and function and an association between deficient placental development, oxidative stress, and micronutrient deficiency has been observed. Selenium and iodine are two essential micronutrients with antioxidant properties. Epidemiological studies have shown that poor micronutrient status in pregnant women is associated with a higher incidence of pregnancy complications. The aim of this study was to determine how selenium, iodine, and their combination impact oxidative stress in placental trophoblast cells. HTR8/SVneo extravillous trophoblasts were supplemented with a concentration range of organic and inorganic selenium, potassium iodide, or their combination for 24 h. Oxidative stress was then induced by treating cells with menadione or H2O2 for 24 h. Cell viability and lipid peroxidation as the biomarker of oxidative stress were assessed at 48 h. Both menadione and H2O2 reduced cell viability and increased lipid peroxidation (P < 0.05). Greater cell viability was found in selenium-supplemented cells when compared with vehicle treated cells (P < 0.05). Selenium and iodine supplementation separately or together were associated with lower lipid peroxidation compared with vehicle control (P < 0.05). Supplementation with the combination of selenium and iodine resulted in a greater reduction in lipid peroxidation compared with selenium or iodine alone (P < 0.05). Oxidative stress negatively impacts trophoblast cell survival and cellular integrity. Selenium and iodine protect placental trophoblasts against oxidative stress. Further research is warranted to investigate the molecular mechanisms by which selenium and iodine act in the human placenta.
Keywords: Iodine; Lipid peroxidation; Oxidative stress; Placenta; Reactive oxygen species; Selenium
Rights: © Springer Science+Business Media, LLC, part of Springer Nature 2020
RMID: 1000023084
DOI: 10.1007/s12011-020-02277-7
Grant ID: http://purl.org/au-research/grants/nhmrc/GNT1161079
http://purl.org/au-research/grants/nhmrc/GNT1174971
Appears in Collections:Molecular and Biomedical Science publications

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