Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/127098
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Type: Journal article
Title: The metabolic syndrome in pregnancy and its association with child telomere length
Author: McAninch, D.
Bianco-Miotto, T.
Gatford, K.L.
Leemaqz, S.Y.
Andraweera, P.H.
Garrett, A.
Plummer, M.D.
Dekker, G.A.
Roberts, C.T.
Smithers, L.G.
Grieger, J.A.
Citation: Diabetologia, 2020; 63(10):2140-2149
Publisher: Springer-Verlag
Issue Date: 2020
ISSN: 0012-186X
1432-0428
Statement of
Responsibility: 
Dale McAninch, Tina Bianco-Miotto, Kathy L. Gatford, Shalem Y. Leemaqz, Prabha H. Andraweera, Amy Garrett, Michelle D. Plummer, Gus A. Dekker, Claire T. Roberts, Lisa G. Smithers, Jessica A. Grieger
Abstract: Aims/Hypothesis: The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age. Methods: The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international prospective cohort of nulliparous pregnant women recruited from Australia, New Zealand, Ireland and the UK (N = 5628). The current analysis is a 10 year follow-up of SCOPE pregnant women and their children, from the Australian cohort. Clinical data collected at 14-16 weeks' gestation during the SCOPE study were used to diagnose the metabolic syndrome using IDF criteria. Telomere length, a biomarker of ageing, was assessed by quantitative PCR from children's saliva collected at 10 years of age. Results: In women who completed follow-up (n = 255), 20% had the metabolic syndrome in pregnancy. After adjusting for a range of confounders, children of mothers who had the metabolic syndrome in pregnancy had 14% shorter telomeres than children of mothers without the metabolic syndrome in pregnancy (mean difference -0.36 [95% CI -0.74, 0.01]). Height- and weight-for-age, and BMI z scores were similar in children of mothers who did and did not have the metabolic syndrome during pregnancy. Conclusions/Interpretation: Children of mothers who had the metabolic syndrome in pregnancy have shorter telomeres, a biomarker of accelerated ageing. These findings warrant further studies in larger cohorts of children, as well as investigations into whether telomere length measured in cord blood associates with telomere length in childhood.
Keywords: Cardiovascular; children; developmental programming; maternal; metabolic syndrome; obesity; offspring; pregnancy; telomere length
Rights: © Springer-Verlag GmbH Germany, part of Springer Nature 2020
RMID: 1000024015
DOI: 10.1007/s00125-020-05242-0
Grant ID: http://purl.org/au-research/grants/nhmrc/GNT1090778
http://purl.org/au-research/grants/nhmrc/GNT1174971
Appears in Collections:Medicine publications

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