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https://hdl.handle.net/2440/127121
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Type: | Journal article |
Title: | A reappraisal of circulating fetal cell noninvasive prenatal testing |
Author: | Rezaei, M. Winter, M. Zander-Fox, D. Whitehead, C. Liebelt, J. Warkiani, M.E. Hardy, T. Thierry, B. |
Citation: | Trends in Biotechnology, 2019; 37(6):632-644 |
Publisher: | Elsevier |
Issue Date: | 2019 |
ISSN: | 0167-7799 1879-3096 |
Statement of Responsibility: | Meysam Rezaei, Marnie Winter, Deirdre Zander-Fox, Clare Whitehead, Jan Liebelt ...Tristan Hardy ... et al. |
Abstract: | New tools for higher-resolution fetal genome analysis including microarray and next-generation sequencing have revolutionized prenatal screening. This article provides commentary on this rapidly advancing field and a future perspective emphasizing circulating fetal cell (CFC) utility. Despite the tremendous technological challenges associated with their reliable and cost-effective isolation from maternal blood, CFCs have a strong potential to bridge the gap between the diagnostic sensitivity of invasive procedures and the desirable noninvasive nature of cell-free fetal DNA (cffDNA). Considering the rapid advances in both rare cell isolation and low-input DNA analysis, we argue here that CFC-based noninvasive prenatal testing is poised to be implemented clinically in the near future. |
Keywords: | circulating fetal cell noninvasive prenatal testing prenatal screening rare cells |
Rights: | © 2018 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.tibtech.2018.11.001 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1045841 |
Published version: | http://dx.doi.org/10.1016/j.tibtech.2018.11.001 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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