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|Title:||A reappraisal of circulating fetal cell noninvasive prenatal testing|
|Citation:||Trends in Biotechnology, 2019; 37(6):632-644|
|Meysam Rezaei, Marnie Winter, Deirdre Zander-Fox, Clare Whitehead, Jan Liebelt ...Tristan Hardy ... et al.|
|Abstract:||New tools for higher-resolution fetal genome analysis including microarray and next-generation sequencing have revolutionized prenatal screening. This article provides commentary on this rapidly advancing field and a future perspective emphasizing circulating fetal cell (CFC) utility. Despite the tremendous technological challenges associated with their reliable and cost-effective isolation from maternal blood, CFCs have a strong potential to bridge the gap between the diagnostic sensitivity of invasive procedures and the desirable noninvasive nature of cell-free fetal DNA (cffDNA). Considering the rapid advances in both rare cell isolation and low-input DNA analysis, we argue here that CFC-based noninvasive prenatal testing is poised to be implemented clinically in the near future.|
|Keywords:||circulating fetal cell|
noninvasive prenatal testing
|Rights:||© 2018 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Aurora harvest 4|
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