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Type: Journal article
Title: A reappraisal of circulating fetal cell noninvasive prenatal testing
Author: Rezaei, M.
Winter, M.
Zander-Fox, D.
Whitehead, C.
Liebelt, J.
Warkiani, M.
Hardy, T.
Thierry, B.
Citation: Trends in Biotechnology, 2019; 37(6):632-644
Publisher: Elsevier
Issue Date: 2019
ISSN: 0167-7799
Statement of
Meysam Rezaei, Marnie Winter, Deirdre Zander-Fox, Clare Whitehead, Jan Liebelt ...Tristan Hardy ... et al.
Abstract: New tools for higher-resolution fetal genome analysis including microarray and next-generation sequencing have revolutionized prenatal screening. This article provides commentary on this rapidly advancing field and a future perspective emphasizing circulating fetal cell (CFC) utility. Despite the tremendous technological challenges associated with their reliable and cost-effective isolation from maternal blood, CFCs have a strong potential to bridge the gap between the diagnostic sensitivity of invasive procedures and the desirable noninvasive nature of cell-free fetal DNA (cffDNA). Considering the rapid advances in both rare cell isolation and low-input DNA analysis, we argue here that CFC-based noninvasive prenatal testing is poised to be implemented clinically in the near future.
Keywords: circulating fetal cell
noninvasive prenatal testing
prenatal screening
rare cells
Rights: © 2018 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.tibtech.2018.11.001
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