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https://hdl.handle.net/2440/127121
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dc.contributor.author | Rezaei, M. | - |
dc.contributor.author | Winter, M. | - |
dc.contributor.author | Zander-Fox, D. | - |
dc.contributor.author | Whitehead, C. | - |
dc.contributor.author | Liebelt, J. | - |
dc.contributor.author | Warkiani, M.E. | - |
dc.contributor.author | Hardy, T. | - |
dc.contributor.author | Thierry, B. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Trends in Biotechnology, 2019; 37(6):632-644 | - |
dc.identifier.issn | 0167-7799 | - |
dc.identifier.issn | 1879-3096 | - |
dc.identifier.uri | http://hdl.handle.net/2440/127121 | - |
dc.description.abstract | New tools for higher-resolution fetal genome analysis including microarray and next-generation sequencing have revolutionized prenatal screening. This article provides commentary on this rapidly advancing field and a future perspective emphasizing circulating fetal cell (CFC) utility. Despite the tremendous technological challenges associated with their reliable and cost-effective isolation from maternal blood, CFCs have a strong potential to bridge the gap between the diagnostic sensitivity of invasive procedures and the desirable noninvasive nature of cell-free fetal DNA (cffDNA). Considering the rapid advances in both rare cell isolation and low-input DNA analysis, we argue here that CFC-based noninvasive prenatal testing is poised to be implemented clinically in the near future. | - |
dc.description.statementofresponsibility | Meysam Rezaei, Marnie Winter, Deirdre Zander-Fox, Clare Whitehead, Jan Liebelt ...Tristan Hardy ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2018 Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.tibtech.2018.11.001 | - |
dc.subject | circulating fetal cell | - |
dc.subject | noninvasive prenatal testing | - |
dc.subject | prenatal screening | - |
dc.subject | rare cells | - |
dc.title | A reappraisal of circulating fetal cell noninvasive prenatal testing | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.tibtech.2018.11.001 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1045841 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hardy, T. [0000-0002-5878-0340] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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