Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/127122
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Type: Journal article
Title: Biocompatible porous polyester-ether hydrogel scaffolds with cross-linker mediated biodegradation and mechanical properties for tissue augmentation
Author: Ozcelik, B.
Palmer, J.
Ladewig, K.
Facal Marina, P.
Stevens, G.W.
Abberton, K.
Morrison, W.A.
Blencowe, A.
Qiao, G.G.
Citation: Polymers, 2018; 10(2):1-19
Publisher: MDPI
Issue Date: 2018
ISSN: 2073-4360
2073-4360
Statement of
Responsibility: 
Berkay Ozcelik, Jason Palmer, Katharina Ladewig, Paula Facal Marina, Geoffrey W. Stevens, Keren Abberton ...et al.
Abstract: Porous polyester-ether hydrogel scaffolds (PEHs) were fabricated using acid chloride/alcohol chemistry and a salt templating approach. The PEHs were produced from readily available and cheap commercial reagents via the reaction of hydroxyl terminated poly(ethylene glycol) (PEG) derivatives with sebacoyl, succinyl, or trimesoyl chloride to afford ester cross-links between the PEG chains. Through variation of the acid chloride cross-linkers used in the synthesis and the incorporation of a hydrophobic modifier (poly(caprolactone) (PCL)), it was possible to tune the degradation rates and mechanical properties of the resulting hydrogels. Several of the hydrogel formulations displayed exceptional mechanical properties, remaining elastic without fracture at compressive strains of up to 80%, whilst still displaying degradation over a period of weeks to months. A subcutaneous rat model was used to study the scaffolds in vivo and revealed that the PEHs were infiltrated with well vascularised tissue within two weeks and had undergone significant degradation in 16 weeks without any signs of toxicity. Histological evaluation for immune responses revealed that the PEHs incite only a minor inflammatory response that is reduced over 16 weeks with no evidence of adverse effects.
Keywords: biocompatible; biodegradation; hydrogel; polyester-ether; scaffold
Rights: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
RMID: 1000024314
DOI: 10.3390/polym10020179
Grant ID: http://purl.org/au-research/grants/arc/FT110100411
http://purl.org/au-research/grants/arc/FS110200025
http://purl.org/au-research/grants/nhmrc/1064786
Appears in Collections:Medicine publications

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