Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/127200
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Type: Journal article
Title: Permeability measures predict hemorrhagic transformation after ischemic stroke
Author: Bivard, A.
Kleinig, T.
Churilov, L.
Levi, C.
Lin, L.
Cheng, X.
Chen, C.
Aviv, R.
Choi, P.
Spratt, N.J.
Butcher, K.
Dong, Q.
Parsons, M.
Citation: Annals of Neurology, 2020; 88(3):466-476
Publisher: Wiley
Issue Date: 2020
ISSN: 0364-5134
1531-8249
Statement of
Responsibility: 
Andrew Bivard, Timothy Kleinig, Leonid Churilov, Christopher Levi, Longting Lin, Xin Cheng, Chushuang Chen, Richard Aviv, Philip M.C. Choi, Neil J. Spratt, Kenneth Butcher, Qiang Dong and Mark Parsons
Abstract: Objective: We sought to examine the diagnostic utility of existing predictors of any haemorrhagic transformation (HT) and compare them to novel perfusion imaging permeability measures in ischemic stroke patients receiving alteplase only. Methods: A pixel-based analysis of pre-treatment CT perfusion (CTP) was undertaken to define the optimum CTP permeability thresholds to predict the likelihood of HT. We then compared previously proposed predictors of HT using regression analyses and receiver operator characteristic curve analysis to produce an Area Under the Cure (AUC), and compared AUCs using Chi Square analysis. Results: From 5 centres, 1407 patients were included in this study, 282 had HT. The cohort was split into a derivation (1025, 70% patients) and validation cohort (382 patients or 30%). The E permeability map at a threshold of 30% relative to contralateral had the highest AUC at predicting any HT (derivation AUC 0.85, 95% CI, 0.79-0.91, validation AUC 0.84, 95% CI, 0.77-0.91). The AUC improved when permeability was assessed within the acute perfusion lesion for the E maps at a threshold of 30% (derivation AUC 0.91, 95% CI, 0.86-0.95, validation AUC 0.89, 95% CI, 0.86-0.95). Previously proposed associations with HT and PH showed lower AUC values than the permeability measure. Interpretation: In this large multi-centre study, we have validated a highly accurate measure of HT prediction. This measure may be useful in clinical practice to predict haemorrhagic transformation in ischemic stroke patients before receiving alteplase alone.
Keywords: Stroke; hemorrhage
Rights: © 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
RMID: 1000021162
DOI: 10.1002/ana.25785
Grant ID: http://purl.org/au-research/grants/nhmrc/1013719
Appears in Collections:Medicine publications

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