Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/127399
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Type: Journal article
Title: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders: evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group
Author: Opel, N.
Thalamuthu, A.
Milaneschi, Y.
Grotegerd, D.
Flint, C.
Leenings, R.
Goltermann, J.
Richter, M.
Hahn, T.
Woditsch, G.
Berger, K.
Hermesdorf, M.
McIntosh, A.
Whalley, H.C.
Harris, M.A.
MacMaster, F.P.
Walter, H.
Veer, I.M.
Frodl, T.
Carballedo, A.
et al.
Citation: Molecular Psychiatry, 2021; 26(9):4839-4852
Publisher: Springer
Issue Date: 2021
ISSN: 1359-4184
1476-5578
Statement of
Responsibility: 
Nils Opel ... Bernhard T. Baune ... et al.
Abstract: Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data (n = 3907) from the ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical and subcortical abnormalities in both mass-univariate and multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found for associations between obesity and lower temporo-frontal cortical thickness (maximum Cohen´s d (left fusiform gyrus) = −0.33). The observed regional distribution and effect size of cortical thickness reductions in obesity revealed considerable similarities with corresponding patterns of lower cortical thickness in previously published studies of neuropsychiatric disorders. A higher polygenic risk score for obesity significantly correlated with lower occipital surface area. In addition, a significant age-by-obesity interaction on cortical thickness emerged driven by lower thickness in older participants. Our findings suggest a neurobiological interaction between obesity and brain structure under physiological and pathological brain conditions.
Keywords: Brain
Cerebral Cortex
Humans
Obesity
Magnetic Resonance Imaging
Risk Factors
Depressive Disorder, Major
Aged
Description: Published online: 28 May 2020
Rights: © The Author(s) 2020. This article is published with open access, corrected publication 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/.
DOI: 10.1038/s41380-020-0774-9
Grant ID: http://purl.org/au-research/grants/nhmrc/1140764
http://purl.org/au-research/grants/nhmrc/1064643
http://purl.org/au-research/grants/nhmrc/1024570
http://purl.org/au-research/grants/nhmrc/566529
http://purl.org/au-research/grants/nhmrc/264611
http://purl.org/au-research/grants/nhmrc/402864
http://purl.org/au-research/grants/nhmrc/464914
Appears in Collections:Aurora harvest 8
Psychiatry publications

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