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Type: Thesis
Title: Allograft intervertebral disc transplantation in the sheep:an assessment of the potential for allograft disc replacement
Author: Mario, Penta
Issue Date: 1995
School/Discipline: School of Medicine : Orthopaedics and Trauma
Abstract: STUDY DESIGN: An allograft intervertebral disc transplantation procedure was carried out in a total of twenty 2-year old Merino wethers. OBJECTIVE: The aims of this study were to test the viability and integrity of an intervertebral disc following transplantation from one animal to another, and to assess the safety and reliability of the transplant procedure. SUMMARY OF BACKGROUND DATA: Because of the unpredictable clinical results reported in the literature, the role of spinal fusion for chronic disabling back pain associated with degeneration of the intervertebral disc remains controversial. The challenge for the future will be to develop other forms ,,. of spinal stabilisation procedures that may produce better and more reliable results than spinal arthrodesis. Recently, prosthetic intervertebral disc replacement has been developed and trialled in a number of centres but concerns exist regarding the likely long term effects of these implants, particularly those related to loosening, wear particles and infection. Allograft intervertebral disc transplantation, however, may be able to overcome the inherent limitations of artificial disc replacement and may also be able to better withstand the normal physiological demands and restore the function of the motion segment. If successful, allograft disc replacement may become, in theory, an appealing alternative to fusion surgery. METHODS: The study was carried out in a total of twenty 2-year old Merino wethers. uni ts were harvested from which were sacrificed Donor intervertebral an additional eight within four hours disc sheep of transplantation. The disc units were harvested using an oscillating saw and comprised the entire intervertebral disc together with a thin plate of adjacent vertebral bone. A single intervertebral disc unit was inserted into the recipient lumbar spine via an antero-lateral approach under a general anaesthetic and with strict aseptic conditions. Attempted stabilisation of the allograft employing small screws inserted obliquely into the adjacent vertebral bodies proved to be unsatisfactory in the first group of sheep. Internal fixation of adjacent vertebrae with a lateral plate and screws was subsequently used in an attempt to prevent ventral displacement of the disc unit.
Advisor: Fraser, Robert
Dissertation Note: Thesis (M.S.)--University of Adelaide, Dept. of Orthopaedics and Trauma, 1996
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