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Type: Journal article
Title: Epigenetic regulators of mesenchymal stem/stromal cell lineage determination
Author: Cakouros, D.
Gronthos, S.
Citation: Current Osteoporosis Reports, 2020; 18(5):597-605
Publisher: Springer
Issue Date: 2020
ISSN: 1544-1873
Statement of
Dimitrios Cakouros and Stan Gronthos
Abstract: PURPOSE OF REVIEW:Although many signalling pathways have been discovered to be essential in mesenchymal stem/stromal (MSC) differentiation, it has become increasingly clear in recent years that epigenetic regulation of gene transcription is a vital component of lineage determination, encompassing diet, lifestyle and parental influences on bone, fat and cartilage development. RECENT FINDINGS:This review discusses how specific enzymes that modify histone methylation and acetylation or DNA methylation orchestrate the differentiation programs in lineage determination of MSC and the epigenetic changes that facilitate development of bone related diseases such as osteoporosis. The review also describes how environmental factors such as mechanical loading influence the epigenetic signatures of MSC, and how the use of chemical agents or small peptides can regulate epigenetic drift in MSC populations during ageing and disease. Epigenetic regulation of MSC lineage commitment is controlled through changes in enzyme activity, which modifies DNA and histone residues leading to alterations in chromatin structure. The co-ordinated epigenetic regulation of transcriptional activation and repression act to mediate skeletal tissue homeostasis, where deregulation of this process can lead to bone loss during ageing or osteoporosis.
Keywords: DNA methylation; Epigenetics; Histone acetylation; Histone methylation; MSC; Mesenchymal stem/stromal cells; Skeletal stem cells
Description: Published online: 13 August 2020
Rights: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
RMID: 1000025259
DOI: 10.1007/s11914-020-00616-0
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Appears in Collections:Genetics publications

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