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Type: Journal article
Title: Age-related decline of neuroplasticity to intermittent theta burst stimulation of the lateral prefrontal cortex and its relationship with late-life memory performance
Author: Goldsworthy, M.
Rogasch, N.
Ballinger, S.
Graetz, L.
Van Dam, J.
Harris, R.
Yu, S.
Pitcher, J.
Baune, B.
Ridding, M.
Citation: Clinical Neurophysiology, 2020; 131(9):2181-2191
Publisher: Elsevier
Issue Date: 2020
ISSN: 1388-2457
Statement of
Mitchell R. Goldsworthy, Nigel C. Rogasch, Sophie Ballinger, Lynton Graetz, Jago M. Van Dam, Richard Harris ... et al.
Abstract: OBJECTIVE: Advanced age is accompanied by a deterioration in memory performance that can profoundly influence activities of daily living. However, the neural processes responsible for age-related memory decline are not fully understood. Here, we used transcranial magnetic stimulation (TMS) in combination with electroencephalography (EEG) to assess age-related changes in neuroplasticity in the human prefrontal cortex. METHODS: TMS-evoked cortical potentials (TEPs) were recorded before and following the neuroplasticity-inducing intermittent theta burst stimulation (iTBS), applied to the left lateral prefrontal cortex in healthy young (n = 33, mean age 22 ± 3 years) and older adults (n = 33, mean age 68 ± 7 years). RESULTS: iTBS increased the amplitude of the positive TEP component at 60 ms after the TMS pulse (P60) in young, but not older adults. This age-related decline in P60 plasticity response was associated with poorer visuospatial associative (but not working) memory performance in older adults. CONCLUSIONS: These findings suggest that neuroplasticity in the human lateral prefrontal cortex is reduced in older relative to young adults, and this may be an important factor in age-related memory decline. SIGNIFICANCE: This may have important implications for the early detection of cognitive decline and dementia.
Keywords: Ageing; EEG; Neuroplasticity; Prefrontal cortex; Theta burst stimulation; Transcranial magnetic stimulation
Rights: Ó2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rightsreserved.
RMID: 1000023795
DOI: 10.1016/j.clinph.2020.06.015
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Appears in Collections:Medicine publications

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