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Type: Journal article
Title: The impact of obesity and hypercaloric diet consumption on anxiety and emotional behavior across the lifespan
Author: Baker, K.
Loughman, A.
Spencer, S.
Reichelt, A.
Citation: Neuroscience and Biobehavioral Reviews, 2017; 83:173-182
Publisher: Elsevier
Issue Date: 2017
ISSN: 0149-7634
Statement of
Kathryn D. Baker, Amy Loughman, Sarah J. Spencer, Amy C. Reichelt
Abstract: Obesity is an increasing problem in young people. Childhood obesity and overweight have increased rapidly on a global scale, and have tripled in the past 30 years, to affect approximately one in five children. Diets high in refined fats and sugar are a major contributor to the development of obesity, and the effects of such obesity-inducing hypercaloric diets on brain function may contribute to the high prevalence of anxiety disorders in people with obesity. Anxiety disorders typically emerge in childhood and adolescence, and symptoms often continue into adulthood. Based on this symptomology, we consider anxiety-related behavioral consequences of hypercaloric diets across development. We review research on the effects of hypercaloric dietary manipulations across the lifespan on emotion regulation and the neurobiological mechanisms that underpin these processes. Cumulatively, the findings reveal that gestation and the juvenile/adolescent developmental periods may be early-life windows of vulnerability for developing anxiety in later life due to the augmented effects of these diets on neuroendocrine stress systems and the maturation of neural circuitry supporting emotion regulation.
Keywords: Obesity; anxiety; high fat diet; adolescence; neurodevelopment; stress
Rights: © 2017 Elsevier Ltd. All rights reserved.
RMID: 1000025745
DOI: 10.1016/j.neubiorev.2017.10.014
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Appears in Collections:Medicine publications

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