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Type: Journal article
Title: Formulation of nanoparticles using mixing-induced nanoprecipitation for drug delivery
Author: Liu, Y.
Yang, G.
Zou, D.
Hui, Y.
Nigam, K.
Middelberg, A.P.J.
Zhao, C.X.
Citation: Industrial and Engineering Chemistry Research, 2020; 59(9):4134-4149
Publisher: American Chemical Society
Issue Date: 2020
ISSN: 0888-5885
Statement of
Yun Liu, Guangze Yang, Da Zou, Yue Hui, Krishna Nigam, Anton P. J. Middelberg and Chun-Xia Zhao
Abstract: Significant efforts have been made to fabricate drug-loaded nanoparticles for drug delivery. Nanoprecipitation is a simple and versatile method for making various types of polymer nanoparticles with well-controlled particle size, size distribution, and surface properties. This review presents a critical overview of three different widely used nanoprecipitation techniques, namely, traditional nanoprecipitation in bulk solutions, flash nanoprecipitation, and microfluidic-based nanoprecipitation. The review starts with the comparison of these three different nanoprecipitation methods summarizing their key characteristics, advantages, and disadvantages. Then, different types of nanoparticles synthesized using nanoprecipitation are presented including di-block copolymer nanoparticles and natural polymer nanoparticles. A special focus is placed on comparing different drug-loaded polymer nanoparticles prepared using different nanoprecipitation approaches including their synthesis methods, drug loading, encapsulation efficiency, nanoparticle properties (e.g., size, PDI, etc.), and stability. Finally, the principle of forming nanoparticles with well-controlled properties is discussed to fundamentally understand the intricate interplay between mixing, supersaturation, nucleation, and particle growth, aiming to provide a general guideline for making drug-loaded nanoparticles based on nanoprecipitation.
Keywords: Nanoparticles; hydrophobicity; solvents; pharmaceuticals; polymers
Rights: © 2019 American Chemical Society
DOI: 10.1021/acs.iecr.9b04747
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Chemistry and Physics publications

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