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Type: Journal article
Title: Diet-induced modification of the sperm epigenome programs metabolism and behavior
Author: Bodden, C.
Hannan, A.
Reichelt, A.
Citation: Trends in Endocrinology and Metabolism, 2020; 31(2):131-149
Publisher: Elsevier
Issue Date: 2020
ISSN: 1043-2760
Statement of
Carina Bodden, Anthony J.Hannan, Amy C.Reichelt
Abstract: Globally, obesity has reached epidemic proportions. The rapidly increasing numbers of overweight people can be traced back to overconsumption of energy-dense, poor-quality foods as well as physical inactivity. This development has far-reaching and costly implications. Not only is obesity associated with serious physiological and psychological complications, but mounting evidence also indicates a ripple effect through generations via epigenetic changes. Parental obesity could induce intergenerational and transgenerational changes in metabolic and brain function of the offspring. Most research has focused on maternal epigenetic and gestational effects; however, paternal contributions are likely to be substantial. We focus on the latest advances in understanding the mechanisms of epigenetic inheritance of obesity-evoked metabolic and neurobiological changes through the paternal germline that predict wide-ranging consequences for the following generation(s).
Keywords: epigenetics; intergenerational paternal effects; metabolic dysfunction; nongenetic inheritance; obesity; sperm epimutation
Rights: © 2019 Elsevier Ltd. All rights reserved.
RMID: 1000025731
DOI: 10.1016/j.tem.2019.10.005
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Appears in Collections:Medicine publications

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