Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||A bout of voluntary running enhances context conditioned fear, its extinction, and its reconsolidation|
|Citation:||Learning and Memory, 2014; 21(2):73-81|
|Publisher:||Cold Spring Harbor Laboratory Press|
|Joyce Siette, Amy C. Reichelt and R. Frederick Westbrook|
|Abstract:||Three experiments used rats to examine the effect of a single bout of voluntary activity (wheel running) on the acquisition, extinction, and reconsolidation of context conditioned fear. In Experiment 1, rats provided with access to a wheel for 3 h immediately before or after a shocked exposure to a context froze more when tested in that context than rats provided with access to the wheels 6 h after the shocked exposure or rats not provided with access to the wheels. In Experiment 2, rats provided with access to the wheels immediately before or after a nonshocked exposure to the conditioned context froze less when tested in that context than rats provided with access to the wheels 6 h after the nonshocked exposure or rats not provided with access to the wheels. In Experiment 3, rats provided with access to wheels immediately after an extended nonshocked exposure to the conditioned context again froze less, whereas rats provided with access to the wheels after a brief nonshocked exposure froze more on the subsequent test than sedentary controls. These results show that a single bout of running can enhance acquisition, extinction, and reconsolidation of context conditioned fear.|
|Keywords:||Animals; Rats; Rats, Wistar; Electroshock; Freezing Reaction, Cataleptic; Motor Activity; Fear; Conditioning (Psychology); Memory; Running; Time Factors; Male; Extinction, Psychological|
|Rights:||© 2014 Siette et al.; Published by Cold Spring Harbor Laboratory Press. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date. After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http:// creativecommons.org/licenses/by-nc/3.0/|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.