Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/128248
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Endocardial-epicardial phase mapping of prolonged persistent atrial fibrillation recordings: high prevalence of dissociated activation patterns
Author: Parameswaran, R.
Kalman, J.M.
Royse, A.
Goldblatt, J.
Larobina, M.
Watts, T.
Walters, T.E.
Nalliah, C.J.
Wong, G.
Al-Kaisey, A.
Anderson, R.D.
Voskoboinik, A.
Sugumar, H.
Chieng, D.
Sanders, P.
Kistler, P.M.
Gerstenfeld, E.P.
Lee, G.
Citation: Circ Arrhythm Electrophysiol, 2020; 13(8)
Publisher: AHA Journals
Issue Date: 2020
ISSN: 1941-3149
1941-3084
Statement of
Responsibility: 
Ramanathan Parameswaran, Jonathan M. Kalman, Alistair Royse, John Goldblatt ... Prashanthan Sanders ... Geoffrey Wong ... et al.
Abstract: Background - Endocardial-epicardial dissociation (EED) and focal breakthroughs in humans with atrial fibrillation (AF) have been recently demonstrated using activation mapping of short 10-second AF segments. In the current study we used simultaneous endo-epi phase mapping to characterise endo-epi activation patterns on long segments of human persistent AF (PeAF). Methods - Simultaneous intra-operative mapping of endo- and epicardial lateral RA wall was performed in patients with PeAF using two high-density grid catheters (16 electrodes, 3mm spacing). Filtered unipolar and bipolar electrograms (EGM's) of continuous 2-min AF recordings and electrodes locations were exported for phase analyses. We defined EED as phase difference of ≥20ms between paired endo-epi electrodes. Wavefronts (WF) were classified as rotations, single WF (SWF), focal waves or disorganised activity as per standard criteria. Endo-Epi WF patterns were simultaneously compared on dynamic phase maps. Complex fractionated EGM's were defined as bipolar EGM's with ≥5 directional changes occupying at least 70% of sample duration. Results - Fourteen patients with PeAF undergoing cardiac surgery were included. EED was seen in 50.3% of phase maps with significant temporal heterogeneity. Disorganised activity (Endo:41.3% vs Epi:46.8%, p=0.0194) and SWF (Endo:31.3% vs Epi:28.1%, p=0.129) were the dominant patterns. Transient rotations (Endo:22% vs Epi:19.2%, p=0.169; mean duration: 590±140ms) and non-sustained focal waves (Endo:1.2% vs Epi:1.6%, p=0.669) were also observed. Apparent transmural migration of rotational activations (n=6) from the epi- to the endocardium was seen in 2 patients. EGM fractionation was significantly higher in the epicardium than endocardium (61.2% vs 51.6%, p<0.0001). Conclusions - Simultaneous endo-epi phase mapping of prolonged human PeAF recordings shows significant EED marked temporal heterogeneity, discordant and transitioning WF patterns and complex fractionations. No sustained focal activity was observed. Such complex 3D-interactions provide insight into why endocardial mapping alone may not fully characterise the AF mechanism and why endocardial ablation may not be sufficient.
Keywords: Mapping; endocardial-epicardial; atrial fibrillation; fractionation; atrium; human; wavefronts
Description: Originally published 7 Jul 2020
Rights: © 2020 American Heart Association, Inc.
RMID: 1000023104
DOI: 10.1161/CIRCEP.120.008512
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.