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https://hdl.handle.net/2440/128317
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Type: | Journal article |
Title: | Whole-cell pertussis vaccination and decreased Risk of IgE-mediated food allergy: a nested case-control study |
Author: | Estcourt, M.J. Campbell, D.E. Gold, M.S. Richmond, P. Allen, K.J. Quinn, H.E. Marsh, J.A. Peters, R.L. Valerio, C. Dai, D. Waddington, C.S. Wood, N.J. McIntyre, P.B. Holt, P.G. Snelling, T.L. |
Citation: | Journal of Allergy and Clinical Immunology: In Practice, 2019; 8(6):2004-2014 |
Publisher: | Elsevier |
Issue Date: | 2019 |
ISSN: | 2213-2198 2213-2201 |
Statement of Responsibility: | Marie J.Estcourt, Dianne E.Campbell, Michael S.Gold, Peter Richmond, Katrina J.Allen, Helen E.Quinn ... et al. |
Abstract: | BACKGROUND:Rates of food allergy have increased markedly in Australia and other high- income countries in recent years. On the basis of ecological observations, and the known immunologic characteristics of whole-cell pertussis (wP) compared with acellular pertussis (aP) vaccines, we hypothesized that wP vaccination in infancy protects against the development of food allergy. OBJECTIVE:To determine whether infants who receive wP in infancy were less likely to develop IgE-mediated food allergy than those who received aP. METHODS:Retrospective cohort-nested case-control study of Australian children born in the period 1997 to 1999, the period of transition from using wP-containing to aP-containing vaccines. Children diagnosed with IgE-mediated food allergy were individually matched to 10 controls by date of birth, socioeconomic decile, and jurisdiction of birth. The odds ratio of vaccination with wP versus aP among cases and matched controls was calculated using conditional logistic regression. RESULTS:The odds ratio of receiving the first dose as wP (rather than aP) among cases of food allergy compared with controls was 0.77 (95% CI, 0.62-0.95). The results of secondary analyses (any dose as wP vs aP-only, and wP-only vs aP-only) were broadly similar. CONCLUSIONS:Australian infants who received wP vaccines were less likely to be diagnosed with food allergy in childhood than contemporaneous children who received aP vaccines. If a protective effect is confirmed in a randomized controlled trial, wP or mixed wP and aP vaccination schedules could form part of an effective strategy for combating the rise in food allergies. |
Keywords: | Case-control Food allergy Pertussis Vaccination |
Rights: | © 2020 American Academy of Allergy, Asthma & Immunology |
DOI: | 10.1016/j.jaip.2019.12.020 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1069772 http://purl.org/au-research/grants/nhmrc/GNT1111657 |
Published version: | http://dx.doi.org/10.1016/j.jaip.2019.12.020 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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