Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/128383
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dc.contributor.authorEbert, L.en
dc.contributor.authorMacRaild, S.en
dc.contributor.authorDavis, I.en
dc.contributor.authorCebon, J.en
dc.contributor.authorChen, W.en
dc.date.issued2012en
dc.identifier.citationJournal of Immunological Methods, 2012; 377(1-2):56-61en
dc.identifier.issn0022-1759en
dc.identifier.issn1872-7905en
dc.identifier.urihttp://hdl.handle.net/2440/128383-
dc.description.abstractAntigenic epitopes recognized by FoxP3(+) regulatory T cells (Treg) are poorly defined, largely due to a lack of assays for determining Treg specificity. We have developed a novel approach for detecting human Treg specific to peptide antigen, utilizing down-regulation of surface CD3 as a read-out of antigen recognition. Culture conditions and re-stimulation time have been optimized, allowing the detection of even very rare Treg, such as those specific to tumor antigens.en
dc.description.statementofresponsibilityLisa M.Ebert, Sarah E.MacRaild, Ian D.Davis, Jonathan Cebon, Weisan Chenen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2012 Elsevier B.V. All rights reserved.en
dc.subjectFox P3, Antigen-specific regulatory T cells; CD3 down-regulation; NY-ESO-1en
dc.titleA novel method for detecting antigen-specific human regulatory T cellsen
dc.typeJournal articleen
dc.identifier.rmid1000026724en
dc.identifier.doi10.1016/j.jim.2012.01.004en
dc.identifier.pubid549285-
pubs.library.collectionBiochemistry publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidEbert, L. [0000-0002-8041-9666]en
Appears in Collections:Biochemistry publications

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