Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/128407
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Type: Journal article
Title: Gender-dependent radiotherapy: The next step in personalised medicine?
Author: De Courcy, L.
Bezak, E.
Marcu, L.G.
Citation: Critical Reviews in Oncology Hematology, 2020; 147:102881-1-102881-8
Publisher: Elsevier BV
Issue Date: 2020
ISSN: 1040-8428
1879-0461
Statement of
Responsibility: 
Louis De Courcy, Eva Bezak, Loredana G. Marcu
Abstract: Individuals do not react to radiation in a homogeneous manner. Recent radiogenomic research has proven that individual polymorphisms can correlate with treatment response most likely due to variation in the ability to recognise and repair DNA breaks. The difference in radiosensitivity between genders has been well documented, yet most radiotherapeutic guidelines are based solely on population averages rather than demographic subgroups such as age, race and gender. This paper is a review of the burgeoning literature available on the differences in efficacy and outcome of radiotherapy between genders. The work examines the effect of radiation on gender both from a tumour control as well as normal tissue toxicity perspective. While the literature reporting such findings is limited, the results show a small but significant difference in response to radiotherapy between sexes. Prospective and retrospective studies for evaluating these gender-specific differences are encouraged as a next step in personalised medicine.
Keywords: Radiotherapy
Sex
Gender
Personalised medicine
Treatment outcome
Rights: © 2020 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.critrevonc.2020.102881
Appears in Collections:Aurora harvest 8
Physics publications

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