Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/128422
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Type: Journal article
Title: A review of factors influencing non-adherence to oral antineoplastic drugs
Author: Skrabal Ross, X.
Gunn, K.M.
Suppiah, V.
Patterson, P.
Olver, I.
Citation: Supportive Care in Cancer, 2020; 28(9):4043-4050
Publisher: Springer
Issue Date: 2020
ISSN: 0941-4355
1433-7339
Statement of
Responsibility: 
Xiomara Skrabal Ross, Kate M. Gunn, Vijayaprakash Suppiah, Pandora Patterson and Ian Olver
Abstract: PURPOSE: Adherence to oral antineoplastic drugs is a complex phenomenon, and knowledge about the reasons that people with cancer do not adhere to their prescriptions is essential to inform adherence-related support in clinical and research contexts. This study aims to provide an up-to-date summary of the key reasons for non-adherence to oral antineoplatic drugs (OAD) in people with cancer. METHODS: Electronic databases Medline, Embase, Emcare, and PsychINFO were searched for systematic reviews and studies published between January 2010 and March 2018. Data was analyzed and extracted by two independent reviewers. RESULTS: Three systematic reviews and two studies were included in the review. Key factors for non-adherence were classified as either modifiable or non-modifiable factors. Side effects, forgetfulness, and poor knowledge about OAD were identified as modifiable factors while co-payment, age, regimen complexity. and time since diagnosis were identified as non-modifiable factors. Most of the included studies focused on breast cancer and chronic myeloid leukemia (CML) patients. Low methodological quality and different adherence cut-off rates were observed in the included literature. CONCLUSIONS: More research with rigorous methodology and diverse cancer types is needed to increase evidence on the reasons for OAD non-adherence. However, findings from this study may serve to aid in drafting guidelines and suitable interventions for adherence-related support to OAD users.
Keywords: Cancer
Factors
Medication adherence
Oncology
Oral antineoplastic drugs
Rights: © Springer-Verlag GmbH Germany, part of Springer Nature 2020
DOI: 10.1007/s00520-020-05469-y
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