Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Perineuronal nets: plasticity, protection, and therapeutic potential|
|Citation:||Trends in Neurosciences, 2019; 42(7):458-470|
|Amy C. Reichelt, Dominic J. Hare, Timothy J. Bussey, and Lisa M. Saksida|
|Abstract:||The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins.|
|Rights:||© 2019 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Aurora harvest 8|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.