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Type: Journal article
Title: Perineuronal nets: plasticity, protection, and therapeutic potential
Author: Reichelt, A.
Hare, D.
Bussey, T.
Saksida, L.
Citation: Trends in Neurosciences, 2019; 42(7):458-470
Publisher: Elsevier
Issue Date: 2019
ISSN: 0166-2236
Statement of
Amy C. Reichelt, Dominic J. Hare, Timothy J. Bussey, and Lisa M. Saksida
Abstract: The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins.
Keywords: Neuroprotection
Rights: © 2019 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.tins.2019.04.003
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