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|Title:||Perineuronal nets: plasticity, protection, and therapeutic potential|
|Citation:||Trends in Neurosciences, 2019; 42(7):458-470|
|Amy C. Reichelt, Dominic J. Hare, Timothy J. Bussey, and Lisa M. Saksida|
|Abstract:||The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins.|
|Rights:||© 2019 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Medicine publications|
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