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https://hdl.handle.net/2440/128451
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Type: | Journal article |
Title: | Perineuronal nets: plasticity, protection, and therapeutic potential |
Author: | Reichelt, A.C. Hare, D.J. Bussey, T.J. Saksida, L.M. |
Citation: | Trends in Neurosciences, 2019; 42(7):458-470 |
Publisher: | Elsevier |
Issue Date: | 2019 |
ISSN: | 0166-2236 1878-108X |
Statement of Responsibility: | Amy C. Reichelt, Dominic J. Hare, Timothy J. Bussey, and Lisa M. Saksida |
Abstract: | The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins. |
Keywords: | Neuroprotection |
Rights: | © 2019 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.tins.2019.04.003 |
Grant ID: | http://purl.org/au-research/grants/arc/DP180101974 http://purl.org/au-research/grants/nhmrc/1122981 |
Published version: | http://dx.doi.org/10.1016/j.tins.2019.04.003 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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