Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/128713
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Type: Journal article
Title: Vessel-derived angiocrine IGF1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
Author: Marchant, C.
Anderson, P.
Schwarz, Q.
Wiszniak, S.
Citation: Development, 2020; 147(11):1-8
Publisher: Company of Biologists
Issue Date: 2020
ISSN: 0950-1991
1477-9129
Statement of
Responsibility: 
Ceilidh Marchant, Peter Anderson, Quenten Schwarz and Sophie Wiszniak
Abstract: Craniofacial development is a complex morphogenic process that requires highly orchestrated interactions between multiple cell types. Blood vessel-derived angiocrine factors are known to promote proliferation of chondrocytes in Meckel’s cartilage to drive jaw outgrowth, however the specific factors controlling this process remain unknown. Here, we use in vitro and ex vivo cell and tissue culture, as well as genetic mouse models, to identify IGF1 as a novel angiocrine factor directing Meckel’s cartilage growth during embryonic development. We show that IGF1 is secreted by blood vessels and that deficient IGF1 signalling underlies mandibular hypoplasia in Wnt1-Cre; Vegfafl/fl mice that exhibit vascular and associated jaw defects. Furthermore, conditional removal of IGF1 from blood vessels causes craniofacial defects including a shortened mandible, and reduced proliferation of Meckel’s cartilage chondrocytes. This demonstrates a crucial angiocrine role for IGF1 during craniofacial cartilage growth, and identifies IGF1 as a putative therapeutic for jaw and/or cartilage growth disorders.
Keywords: IGF; angiocrine; craniofacial; cartilage; blood vessel, mouse
Rights: © 2020. Published by The Company of Biologists Ltd.
RMID: 1000022813
DOI: 10.1242/dev.190488
Grant ID: http://purl.org/au-research/grants/nhmrc/1144008
Appears in Collections:Environment Institute publications

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