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Type: Journal article
Title: In vivo hippocampal subfield volumes in bipolar disorder—a mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group
Author: Haukvik, U.K.
Gurholt, T.P.
Nerland, S.
Elvsåshagen, T.
Akudjedu, T.N.
Alda, M.
Alnæs, D.
Alonso-Lana, S.
Bauer, J.
Baune, B.T.
Benedetti, F.
Berk, M.
Bettella, F.
Bøen, E.
Bonnín, C.M.
Brambilla, P.
Canales-Rodríguez, E.J.
Cannon, D.M.
Caseras, X.
Dandash, O.
et al.
Citation: Human Brain Mapping, 2020; OnlinePubl:1-14
Publisher: Wiley Online Library
Issue Date: 2020
ISSN: 1065-9471
Statement of
Unn K. Haukvik, Tiril P. Gurholt, Stener Nerland, Torbjørn Elvsåshagen, Theophilus N. Akudjedu, Martin Alda ... et al.
Abstract: The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.
Keywords: Bipolar disorder subtype; hippocampus; large‐scale; lithium; psychosis; structural brain MRI
Description: First published: 19 October 2020
Rights: © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
RMID: 1000027810
DOI: 10.1002/hbm.25249
Grant ID:
Appears in Collections:Medicine publications

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