Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/129654
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Type: Journal article
Title: Early-life antibiotic-driven dysbiosis leads to dysregulated vaccine immune responses in mice
Author: Lynn, M.
Tumes, D.
Choo, J.
Sribnaia, A.
Blake, S.
Leong, L.
Young, G.
Marshall, H.
Wesselingh, S.
Rogers, G.
Lynn, D.
Citation: Cell Host and Microbe, 2018; 23(5):653-660
Publisher: Elsevier
Issue Date: 2018
ISSN: 1931-3128
1934-6069
Statement of
Responsibility: 
Miriam Anne Lynn, Damon John Tumes, Jocelyn Mei Choo, Anastasia Sribnaia, Stephen James Blake, Lex Ee Xiang Leong ... et al.
Abstract: Antibody-mediated responses play a critical role in vaccine-mediated immunity. However, for reasons that are poorly understood, these responses are highly variable between individuals. Using a mouse model, we report that antibiotic-driven intestinal dysbiosis, specifically in early life, leads to significantly impaired antibody responses to five different adjuvanted and live vaccines. Restoration of the commensal microbiota following antibiotic exposure rescues these impaired responses. In contrast, antibiotic-treated adult mice do not exhibit impaired antibody responses to vaccination. Interestingly, in contrast to impaired antibody responses, immunized mice exposed to early-life antibiotics display significantly enhanced T cell cytokine recall responses upon ex vivo restimulation with the vaccine antigen. Our results demonstrate that, in mice, antibiotic-driven dysregulation of the gut microbiota in early life can modulate immune responses to vaccines that are routinely administered to infants worldwide.
Keywords: CD4(+) T cells
antibiotics
antibody response
early-life
microbiota
vaccines
Rights: © 2018 Elsevier Inc.
DOI: 10.1016/j.chom.2018.04.009
Grant ID: http://purl.org/au-research/grants/nhmrc/1098429
http://purl.org/au-research/grants/nhmrc/1084951
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