Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/129710
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Type: Journal article
Title: Comparison of in vitro fertilisation/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age
Author: McPherson, N.O.
Vincent, A.D.
Pacella-Ince, L.
Tremellen, K.
Citation: Journal of Assisted Reproduction and Genetics, 2021; 38(3):669-678
Publisher: Springer (part of Springer Nature)
Issue Date: 2021
ISSN: 1058-0468
1573-7330
Statement of
Responsibility: 
Nicole O. McPherson, Andrew D. Vincent, Leanne Pacella-Ince and Kelton Tremellen
Abstract: PURPOSE: To determine if the use of ICSI in women of advanced maternal age with non-male factor infertility increases chances of live birth. METHODS: Retrospective data analysis of 10 years of cycle data from a single Australian IVF clinic (Repromed). First cycle patients only of an advanced maternal age (≥ 35 years) with non-male factor infertility utilising standard IVF or ICSI insemination and having at least three oocytes collected at egg pick up were assessed for live birth following transfer of single genetically unscreened blastocyst (N = 577). Subanalysis of clinical pregnancy, miscarriage, fertilisation, embryo utilisation rate and having a blastocyst for transfer were considered. Unadjusted, covariate adjusted and propensity score weighted analysis were performed. RESULTS: The use of standard IVF insemination in women ≥ 35 years with non-male factor infertility increased the chance of a live birth compared with ICSI insemination (unadjusted OR = 2.72, 95% CI [1.78, 4.17]; adjusted OR = 2.64, 95% CI [1.64, 4.27] and weighted OR = 2.26, 95% CI [1.72, 2.98] 31% vs 14%). All other outcomes (fertilisation rate, embryo utilisation, blastocyst for embryo transfer and miscarriage rate) were unaffected. CONCLUSION: In couples with advanced maternal age and non-male factor infertility, standard IVF insemination appears to increase the chance of a live birth compared with ICSI. As such, the results of this study support the use of routine IVF as the preferred insemination technique for older women in non-male factor infertility. However, future randomised controlled trials are still required to assess this policy.
Keywords: Embryology
Fertility
IVF
Infertility
Pregnancy
Description: Published: 07 January 2021. Corrected by: Correction to: Comparison of in vitro fertilisation/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age, in Vol. 38, Issue 3, 679. The original article unfortunately contained a mistake in the first line of the Conclusion section.
Rights: © 2021, The Author(s), under exclusive licence to Springer Science Business Media, LLC part of Springer Nature
DOI: 10.1007/s10815-020-02026-8
Grant ID: http://purl.org/au-research/grants/nhmrc/Peter Doherty Early Career Research Fellow
Appears in Collections:Aurora harvest 8
Obstetrics and Gynaecology publications

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