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Type: Journal article
Title: Manganese import protects Salmonella enterica serovar Typhimurium against nitrosative stress
Author: Yousuf, S.
Karlinsey, J.E.
Neville, S.L.
McDevitt, C.A.
Libby, S.J.
Fang, F.C.
Frawley, E.R.
Citation: Metallomics, 2020; 12(11):1791-1801
Publisher: Royal Society of Chemistry
Issue Date: 2020
ISSN: 1756-5901
Statement of
Shehla Yousuf, Joyce E. Karlinsey, Stephanie L. Neville, Christopher A. McDevitt, Stephen J. Libby, Ferric C. Fang and Elaine R. Frawley
Abstract: Nitric oxide (NO•) is a radical molecule produced by mammalian phagocytic cells as part of the innate immune response to bacterial pathogens. It exerts its antimicrobial activity in part by impairing the function of metalloproteins, particularly those containing iron and zinc cofactors. The pathogenic Gram-negative bacterium Salmonella enterica serovar typhimurium undergoes dynamic changes in its cellular content of the four most common metal cofactors following exposure to NO• stress. Zinc, iron and magnesium all decrease in response to NO• while cellular manganese increases significantly. Manganese acquisition is driven primarily by increased expression of the mntH and sitABCD transporters following derepression of MntR and Fur. ZupT also contributes to manganese acquisition in response to nitrosative stress. S. Typhimurium mutants lacking manganese importers are more sensitive to NO•, indicating that manganese is important for resistance to nitrosative stress.
Rights: This journal is © The Royal Society of Chemistry 2020
RMID: 1000027475
DOI: 10.1039/d0mt00178c
Grant ID:
Appears in Collections:Molecular and Biomedical Science publications

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