Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/129734
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorYousuf, S.en
dc.contributor.authorKarlinsey, J.E.en
dc.contributor.authorNeville, S.L.en
dc.contributor.authorMcDevitt, C.A.en
dc.contributor.authorLibby, S.J.en
dc.contributor.authorFang, F.C.en
dc.contributor.authorFrawley, E.R.en
dc.date.issued2020en
dc.identifier.citationMetallomics, 2020; 12(11):1791-1801en
dc.identifier.issn1756-5901en
dc.identifier.issn1756-591Xen
dc.identifier.urihttp://hdl.handle.net/2440/129734-
dc.description.abstractNitric oxide (NO•) is a radical molecule produced by mammalian phagocytic cells as part of the innate immune response to bacterial pathogens. It exerts its antimicrobial activity in part by impairing the function of metalloproteins, particularly those containing iron and zinc cofactors. The pathogenic Gram-negative bacterium Salmonella enterica serovar typhimurium undergoes dynamic changes in its cellular content of the four most common metal cofactors following exposure to NO• stress. Zinc, iron and magnesium all decrease in response to NO• while cellular manganese increases significantly. Manganese acquisition is driven primarily by increased expression of the mntH and sitABCD transporters following derepression of MntR and Fur. ZupT also contributes to manganese acquisition in response to nitrosative stress. S. Typhimurium mutants lacking manganese importers are more sensitive to NO•, indicating that manganese is important for resistance to nitrosative stress.en
dc.description.statementofresponsibilityShehla Yousuf, Joyce E. Karlinsey, Stephanie L. Neville, Christopher A. McDevitt, Stephen J. Libby, Ferric C. Fang and Elaine R. Frawleyen
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.rightsThis journal is © The Royal Society of Chemistry 2020en
dc.titleManganese import protects Salmonella enterica serovar Typhimurium against nitrosative stressen
dc.typeJournal articleen
dc.identifier.rmid1000027475en
dc.identifier.doi10.1039/d0mt00178cen
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1140554en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1180826en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1142695en
dc.relation.granthttp://purl.org/au-research/grants/arc/FT170100006en
dc.identifier.pubid551145-
pubs.library.collectionMolecular and Biomedical Science publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidMcDevitt, C.A. [0000-0003-1596-4841]en
Appears in Collections:Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.