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https://hdl.handle.net/2440/129761
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dc.contributor.author | Tay, J. | - |
dc.contributor.author | Thompson, C.H. | - |
dc.contributor.author | Luscombe-Marsh, N.D. | - |
dc.contributor.author | Noakes, M. | - |
dc.contributor.author | Buckley, J.D. | - |
dc.contributor.author | Wittert, G.A. | - |
dc.contributor.author | Brinkworth, G.D. | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Diabetes Research and Clinical Practice, 2020; 170:1-12 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.issn | 1872-8227 | - |
dc.identifier.uri | http://hdl.handle.net/2440/129761 | - |
dc.description.abstract | Background: Growing evidence supports use of very low-carbohydrate (LC) diets for glycaemic control in type 2 diabetes. However, limited data on the micronutrient adequacy of LC diets exist. Objective: This study compared the long-term effects of a very low-carbohydrate, high unsaturated/low saturated fat (LC) diet to a high-carbohydrate, low-fat (HC) diet on micronutrient biomarkers in adults with obesity and type 2 diabetes. Methods: 115 adults with type 2 diabetes (mean[SD]; BMI:34.6[4.3]kg/m², age:58[7]yrs, HbA1c:7.3[1.1]%, 56[12]mmol/mol) were randomized to one of two planned, nutritionally-replete, energy-matched, hypocaloric diets (500-1000kcal/day deficit): (1) LC:14% energy carbohydrate, 28%protein, 58%fat[<10% saturated fat]) or (2) HC:53%carbohydrate, 17%protein, 30%fat [<10%saturated fat]) for 2 years. Nutritional biomarkers- folate, β-carotene, vitamin B12, D, E, copper, zinc, selenium, calcium, magnesium, sodium, potassium, iron, ferritin, transferrin and transferrin saturation were measured in fasting blood at baseline, 24, 52 and 104 weeks. Results: 61 participants completed the study with similar dropouts in each group (P=0.40). For all biomarkers assessed, there were no differential response between groups overtime (P≥0.17 time x diet interaction). Mean vitamin and mineral levels remained within normal (laboratory-specific) reference ranges without any reported cases of clinical deficiencies. Conclusion: In free-living individuals with type 2 diabetes, nutrition biomarkers within normal ranges at baseline did not change significantly after 2 years on a prescribed LC or HC diet. These results demonstrate the feasibility of delivering a nutritionally replete LC diet and the importance of considering nutritional factors in planning LC diets that have strong public health relevance to the dietary management of type 2 diabetes. | - |
dc.description.statementofresponsibility | Jeannie Tay, Campbell H. Thompson, Natalie D. Luscombe-Marsh, Manny Noakes, Jonathan D. Buckley, Gary A. Wittert, Grant D. Brinkworth | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2020 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.diabres.2020.108501 | - |
dc.subject | Diet; low-carbohydrate; nutritional adequacy; type 2 diabetes; weight loss | - |
dc.title | Nutritional adequacy of very low- and high-carbohydrate, low saturated fat diets in adults with type 2 diabetes: a secondary analysis of a 2-year randomised controlled trial | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.diabres.2020.108501 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/103415 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Thompson, C.H. [0000-0002-5164-3327] | - |
dc.identifier.orcid | Luscombe-Marsh, N.D. [0000-0001-9690-4722] | - |
dc.identifier.orcid | Wittert, G.A. [0000-0001-6818-6065] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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