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Type: Journal article
Title: Macrophages in multiple myeloma: key roles and therapeutic strategies
Author: Opperman, K.S.
Vandyke, K.
Psaltis, P.J.
Noll, J.E.
Zannettino, A.C.W.
Citation: Cancer and Metastasis Reviews, 2021; 40(1):273-284
Publisher: Springer
Issue Date: 2021
ISSN: 0167-7659
Statement of
Khatora S. Opperman, Kate Vandyke, Peter J. Psaltis, Jacqueline E. Noll and Andrew C. W. Zannettino
Abstract: Macrophages are a vital component of the tumour microenvironment and crucial mediators of tumour progression. In the last decade, significant strides have been made in understanding the crucial functional roles played by macrophages in the development of the plasma cell (PC) malignancy, multiple myeloma (MM). Whilst the interaction between MM PC and stromal cells within the bone marrow (BM) microenvironment has been extensively studied, we are only just starting to appreciate the multifaceted roles played by macrophages in disease progression. Accumulating evidence demonstrates that macrophage infiltration is associated with poor overall survival in MM. Indeed, macrophages influence numerous pathways critical for the initiation and progression of MM, including homing of malignant cells to BM, tumour cell growth and survival, drug resistance, angiogenesis and immune suppression. As such, therapeutic strategies aimed at targeting macrophages within the BM niche have promise in the clinical setting. This review will discuss the functions elicited by macrophages throughout different stages of MM and provide a comprehensive evaluation of potential macrophage-targeted therapies.
Keywords: Multiple myeloma; macrophages; therapeutics; microenvironment
Description: Published: 06 January 2021
Rights: © Springer Science+Business Media, LLC, part of Springer Nature 2021
DOI: 10.1007/s10555-020-09943-1
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