Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/129905
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Type: Journal article
Title: Self-detoxifying hollow zinc silica nanospheres with tunable Ag ion release-recapture capability: a nanoantibiotic for efficient MRSA inhibition
Author: Wu, H.
Tian, H.
Li, J.
Liu, L.
Wang, Y.
Qiu, J.
Wang, S.
Liu, S.
Citation: Composites Part B: Engineering, 2020; 202:108415-1-108415-10
Publisher: Elsevier
Issue Date: 2020
ISSN: 1359-8368
1879-1069
Statement of
Responsibility: 
Hong Wu, Hao Tian, Jiaquan Li, Lihong Liu, Yuxian Wang, Jieshan Qiu, Shaobin Wang, Shaomin Liu
Abstract: Nanoparticle-enabled strategies to combat antimicrobial-resistant (AMR) bacteria are highly demanded, which hopefully can overcome the barriers associated with conventional antibiotics to achieve high therapeutic efficacy by improving pharmacokinetics. Here, we report the controlled fabrication of multiple Ag nanoparticles (AgNPs) containing ZIF-8 derived hollow -Zn-O-Si- nanospheres with mesoporous wall, Ag&Zn@mesSiO₂, which can release and recapture Ag⁺ ions, thus, efficiently eradicate planktonic methicillin-resistant Staphylococcus aureus (MRSA) in vivo. The AgNPs encapsulated inside the large internal cavities of the hollow structure can kill MRSA at significantly reduced dosages due to the synergistic effect of released Zn and Ag ions, which was 10 times lower in comparison with single Ag⁺ application. The boomerang-like release-and-recapture scheme of the Ag⁺ ions helps to greatly reduce the notorious Ag toxicity. Such novel structured nanocomposites with widened Ag therapeutic window possess great potential as nanoantibiotic for tackling MRSA infection.
Keywords: Silver nanoparticle; ZIF-8; ZnO; mesoporous zinc silica shell; MRSA inhibition
Rights: 2020 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.compositesb.2020.108415
Grant ID: http://purl.org/au-research/grants/arc/DP190103548
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Chemical Engineering publications

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