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|Title:||Temperature and length scale dependence of hydrophobic effects and their possible implications for protein folding|
|Citation:||Proceedings of the National Academy of Sciences of USA, 2000; 97(15):8324-8327|
|Publisher:||National Academy of Sciences|
|David M. Huang and David Chandler|
|Abstract:||The Lum–Chandler–Weeks theory of hydrophobicity [Lum, K., Chandler, D. & Weeks, J. D. (1999) J. Phys. Chem. 103, 4570–4577] is applied to treat the temperature dependence of hydrophobic solvation in water. The application illustrates how the temperature dependence for hydrophobic surfaces extending less than 1 nm differs significantly from that for surfaces extending more than 1 nm. The latter is the result of water depletion, a collective effect, that appears at length scales of 1 nm and larger. Because of the contrasting behaviors at small and large length scales, hydrophobicity by itself can explain the variable behavior of entropies of protein folding.|
|Rights:||Copyright © The National Academy of Sciences|
|Appears in Collections:||Aurora harvest 7|
Chemistry and Physics publications
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