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Type: Journal article
Title: Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial
Author: Berk, M.
Agustini, B.
Woods, R.L.
Nelson, M.R.
Shah, R.C.
Reid, C.M.
Storey, E.
Fitzgerald, S.M.
Lockery, J.E.
Wolfe, R.
Mohebbi, M.
Dodd, S.
Murray, A.M.
Stocks, N.
Fitzgerald, P.B.
Mazza, C.
McNeil, J.J.
Citation: Molecular Psychiatry, 2021; 26(9):5161-5170
Publisher: Springer
Issue Date: 2021
ISSN: 1359-4184
Statement of
Michael Berk, Bruno Agustini, Robyn L. Woods, Mark R. Nelson, Raj C. Shah, Christopher M. Reid ... et al.
Abstract: Late-life depression is common and often inadequately managed using existing therapies. Depression is also associated with increased markers of inflammation, suggesting a potential role for anti-inflammatory agents. ASPREE-D is a sub-study of ASPREE, a large multi-centre, population-based, double-blind, placebo-controlled trial of aspirin vs placebo in older Australian and American adults (median follow-up: 4.7 years) of whom 1879 were depressed at baseline. Participants were given 100 mg daily dose of aspirin or placebo. Depressive symptoms were assessed annually using the validated, self-rated short version of the Center for Epidemiological Studies Depression scale. There was a significant increase in depressive scores (0.6; 95% CI 0.2 to 0.9; χ2 (1)=10.37; p=0.001) and a decreased score in the mental health component of a quality of life scale (–0.7; 95% CI –1.4 to –0.1; χ2 (1)=4.74; p=0.029) in the aspirin group compared to the placebo group. These effects were greater in the first year of follow-up and persisted throughout the study, albeit with small to very small effect sizes. This study failed to demonstrate any benefit of aspirin in the long-term course of depression in this community-dwelling sample of older adults over a 5-year period, and identified an adverse effect of aspirin in the course of depression in those with pre-existing depressive symptoms.
Description: Published online: 27 January 2021
Rights: © The Author(s), under exclusive licence to Springer Nature Limited 2021.
DOI: 10.1038/s41380-021-01020-5
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